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ZNRF4

ZNRF4 (Zinc And Ring Finger 4) is a Protein Coding gene. Diseases associated with ZNRF4 include Deafness, Autosomal Recessive 68 and Deafness, Autosomal Recessive 15. An important paralog of this gene is RNF13.

Full Name

zinc and ring finger 4

Function

E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966).
Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830).
Could have a role in spermatogenesis (By similarity).

Biological Process

Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 28-250
Helical: 251-271
Cytoplasmic: 272-429

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Anti-ZNRF4 antibodies

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Mouse Anti-ZNRF4 Recombinant Antibody (1A8) (CBMAB-Z0698-WJ)

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Target: ZNRF4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A8

Application*: E, WB

Mouse Anti-ZNRF4 Recombinant Antibody (1A8)

Mouse Anti-ZNRF4 Recombinant Antibody (CBWJZ-103) (CBMAB-Z0697-WJ)

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Target: ZNRF4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJZ-103

Application*: SE, E, WB

Mouse Anti-ZNRF4 Recombinant Antibody (CBWJZ-103)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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