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Mouse Anti-ZNRF4 Recombinant Antibody (1A8) (CBMAB-Z0698-WJ)

This product is a mouse antibody that recognizes ZNRF4. The antibody 1A8 can be used for immunoassay techniques such as: ELISA, WB.
See all ZNRF4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
ZNRF4 (AA108-170) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL

Target

Full Name
zinc and ring finger 4
Introduction
ZNRF4 (Zinc And Ring Finger 4) is a Protein Coding gene. Diseases associated with ZNRF4 include Deafness, Autosomal Recessive 68 and Deafness, Autosomal Recessive 15. An important paralog of this gene is RNF13.
Entrez Gene ID
148066
UniProt ID
Q8WWF5
Alternative Names
spzn; RNF204; Ssrzf1; SPERIZIN
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 (PubMed:28656966).
Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830).
Could have a role in spermatogenesis (By similarity).
Biological Process
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 28-250
Helical: 251-271
Cytoplasmic: 272-429
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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