ZW10

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. [provided by RefSeq]

Full Name

ZW10, kinetochore associated, homolog (Drosophila)

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131).
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).

Biological Process

Biological Process cell division Source:UniProtKB-KW
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:HGNC-UCL1 Publication
Biological Process establishment of mitotic spindle orientation Source:UniProtKB1 Publication
Biological Process Golgi organization Source:UniProtKB1 Publication
Biological Process meiotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic metaphase plate congression Source:UniProtKB1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process protein localization to kinetochore Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process protein-containing complex assembly Source:HGNC-UCL1 Publication
Biological Process regulation of exit from mitosis Source:HGNC-UCL1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source:ComplexPortal1 Publication

Cellular Location

Cytoplasm
Endoplasmic reticulum membrane
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Lipid droplet
Note: Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241).
In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237).