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Mouse Anti-ZW10 Recombinant Antibody (CBWJZ-304) (CBMAB-Z0788-WJ)

This product is a mouse antibody that recognizes ZW10. The antibody CBWJZ-304 can be used for immunoassay techniques such as: ICC, IF, IP, WB.
See all ZW10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJZ-304
Antibody Isotype
IgG1
Application
ICC, IF, IP, WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human ZW10, Kinetochore Associated, Homolog (Drosophila).
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL

Target

Full Name
ZW10, kinetochore associated, homolog (Drosophila)
Introduction
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
Entrez Gene ID
9183
UniProt ID
O43264
Alternative Names
HZW10; KNTC1AP
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131).
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:HGNC-UCL1 Publication
Biological Process establishment of mitotic spindle orientation Source:UniProtKB1 Publication
Biological Process Golgi organization Source:UniProtKB1 Publication
Biological Process meiotic cell cycle Source:ProtInc1 Publication
Biological Process mitotic metaphase plate congression Source:UniProtKB1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:UniProtKB1 Publication
Biological Process protein localization to kinetochore Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process protein-containing complex assembly Source:HGNC-UCL1 Publication
Biological Process regulation of exit from mitosis Source:HGNC-UCL1 Publication
Biological Process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source:ComplexPortal1 Publication
Cellular Location
Cytoplasm
Endoplasmic reticulum membrane
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Lipid droplet
Note: Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241).
In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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