AIFM1 Matched Antibody Pair (041) (APMAB-041LY)

Name: AIFM1 Matched Antibody Pair (041)
SKU: APMAB-041LY
Rating: 5 (1 reviews)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-AIFM1 polyclonal antibody, 100 ug

Detection Antibody

Anti-AIFM1 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Aug 2015]

Alternative Names

Apoptosis Inducing Factor Mitochondria Associated 1; Apoptosis-Inducing Factor, Mitochondrion-Associated, 1; Programmed Cell Death 8 (Apoptosis-Inducing Factor); PDCD8; AIF; Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome); Apoptosis Inducing Factor, Mitochondria Associated 1; Apoptosis-Inducing Factor 1, Mitochondrial; Striatal Apoptosis-Inducing Factor; Testicular Secretory Protein Li 4;

Entrez Gene ID

9131

UniProt ID

O95831

More Infomation

References

Hevler, J. F., Chiozzi, R. Z., Cabrera-Orefice, A., Brandt, U., Arnold, S., & Heck, A. J. (2021). Molecular characterization of a complex of Apoptosis Inducing Factor 1 (AIFM1) with cytochrome c oxidase of the mitochondrial respiratory chain. bioRxiv.

Li, Z., Cheng, J., & Liu, J. (2020). Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis. Drug Design, Development and Therapy, 14, 2645.

Bogdanova-Mihaylova, P., Alexander, M. D., Murphy, R. P., Chen, H., Walsh, R. A., & Murphy, S. M. (2019). 138 Clinical spectrum of AIFM1-associated phenotype in an irish family. Journal of Neurology, Neurosurgery and Psychiatry, 90(12), e39.

Wischhof, L., Gioran, A., Sonntag-Bensch, D., Piazzesi, A., Stork, M., Nicotera, P., & Bano, D. (2018). A disease-associated Aifm1 variant induces severe myopathy in knockin mice. Molecular metabolism, 13, 10-23.

Liu, D., Liu, M., Wang, W., Pang, L., Wang, Z., Yuan, C., & Liu, K. (2018). Overexpression of apoptosis-inducing factor mitochondrion-associated 1 (AIFM1) induces apoptosis by promoting the transcription of caspase3 and DRAM in hepatoma cells. Biochemical and biophysical research communications, 498(3), 453-457.

Morton, S. U., Prabhu, S. P., Lidov, H. G., Shi, J., Anselm, I., Brownstein, C. A., ... & Agrawal, P. B. (2017). AIFM1 mutation presenting with fatal encephalomyopathy and mitochondrial disease in an infant. Molecular Case Studies, 3(2), a001560.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-AIFM1 Recombinant Antibody (V2-180343)

Mouse Anti-AIFM1 Recombinant Antibody (V2-610314)

Mouse Anti-AIFM1 Recombinant Antibody (V2-180341)

Mouse Anti-AIFM1 Recombinant Antibody (V2-180344)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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