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AKT2 Matched Antibody Pair (060) (APMAB-060LY)

This antibody pair set can be used for detecting and quantifying protein level of human AKT2.
See all AKT2 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-AKT2 monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-AKT2 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Alternative Names
AKT Serine/Threonine Kinase 2; V-Akt Murine Thymoma Viral Oncogene Homolog 2; Protein Kinase B Beta; Protein Kinase Akt-2; RAC-PK-Beta; EC 2.7.11.1; PKB Beta; Putative V-Akt Murine Thymoma Viral Oncoprotein 2; RAC-Beta Serine/Threonine-Protein Kinase;
Entrez Gene ID
208
UniProt ID
P31751

Li, J., Mo, S., Sun, Y., Huang, H., & Wang, S. (2021). Association between AKT2 gene polymorphism and polycystic ovary syndrome: a case-control study. Gynecological Endocrinology, 1-5.

Palumbo, S., Paterson, C., Yang, F., Hood, V. L., & Law, A. J. (2021). PKBβ/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors. Molecular Psychiatry, 26(2), 411-428.

Plotz, G., Lopez-Garcia, L. A., Brieger, A., Zeuzem, S., & Biondi, R. M. (2020). Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region. PloS one, 15(11), e0242819.

Sharif Siam, M. K., Sarker, A., & Sayeem, M. M. S. (2020). In silico drug design and molecular docking studies targeting Akt1 (RAC-alpha serine/threonine-protein kinase) and Akt2 (RAC-beta serine/threonine-protein kinase) proteins and investigation of CYP (cytochrome P450) inhibitors against MAOB (monoamine oxidase B) for OSCC (oral squamous cell carcinoma) treatment. Journal of Biomolecular Structure and Dynamics, 1-13.

Fiorenza, M. T., Russo, G., Narducci, M. G., Bresin, A., Mangia, F., & Bevilacqua, A. (2020). Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos. Journal of cellular physiology, 235(4), 3393-3401.

Abdelmageed, M. E., Shehatou, G. S., Abdelsalam, R. A., Suddek, G. M., & Salem, H. A. (2019). Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction. Naunyn-Schmiedeberg's archives of pharmacology, 392(2), 243-258.

Lu, Z., Wang, M., Wu, S., Ye, M., Lin, Z., Shun, T., & Duan, C. (2018). MicroRNA‑137‑regulated AKT serine/threonine kinase 2 inhibits tumor growth and sensitizes cisplatin in patients with non‑small cell lung cancer. Oncology letters, 16(2), 1876-1884.

Shen, Y., Gao, Y., Yuan, H., Cao, J., Jia, B., Li, M., ... & Shi, J. (2018). Prohibitin-2 negatively regulates AKT2 expression to promote prostate cancer cell migration. International journal of molecular medicine, 41(2), 1147-1155.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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