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ALOX15 Matched Antibody Pair (068) (APMAB-068LY)

This antibody pair set can be used for detecting and quantifying protein level of human ALOX15.
See all ALOX15 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-ALOX15 monoclonal antibody, 100 ug
Detection Antibody
Anti-ALOX15 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Alternative Names
Arachidonate 15-Lipoxygenase; Arachidonate 12-Lipoxygenase, Leukocyte-Type; Arachidonate Omega-6 Lipoxygenase; 12/15-Lipoxygenase; 15-LOX-1; 12-LOX; 15-LOX; LOG15;
Entrez Gene ID
246
UniProt ID
P16050

Snodgrass, R. G., Benatzy, Y., Schmid, T., Namgaladze, D., Mainka, M., Schebb, N. H., ... & Brüne, B. (2021). Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Cell Death & Differentiation, 28(4), 1301-1316.

Liang, Z., Yan, B., Liu, C., Tan, R., Wang, C., & Zhang, L. (2020). Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps. Allergy, Asthma & Clinical Immunology, 16(1), 1-13.

Rademacher, M., Kuhn, H., & Borchert, A. (2020). Systemic deficiency of mouse arachidonate 15‐lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype. The FASEB Journal, 34(11), 14318-14335.

Yan, B., Wang, Y., Li, Y., Wang, C., & Zhang, L. (2019, March). Inhibition of arachidonate 15‐lipoxygenase reduces the epithelial–mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps. In International forum of allergy & rhinology (Vol. 9, No. 3, pp. 270-280).

Singh, N. K., & Rao, G. N. (2019). Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. Progress in lipid research, 73, 28-45.

Walters, J. L., De Iuliis, G. N., Dun, M. D., Aitken, R. J., McLaughlin, E. A., Nixon, B., & Bromfield, E. G. (2018). Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress. Biology of Reproduction, 98(6), 784-794.

Zhang, W., Zhong, W., Sun, Q., Sun, X., & Zhou, Z. (2017). Hepatic overproduction of 13-HODE due to ALOX15 upregulation contributes to alcohol-induced liver injury in mice. Scientific reports, 7(1), 1-10.

Bromfield, E. G., Mihalas, B. P., Dun, M. D., Aitken, R. J., McLaughlin, E. A., Walters, J. L., & Nixon, B. (2017). Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells. Biology of reproduction, 96(3), 598-609.

Chen, X., Ji, N., Qin, N., Tang, S. A., Wang, R., Qiu, Y., ... & Jin, M. (2017). 1, 6-O, O-Diacetylbritannilactone inhibits eotaxin-1 and ALOX15 expression through inactivation of STAT6 in A549 cells. Inflammation, 40(6), 1967-1974.

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For research use only. Not intended for any clinical use.

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