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Mouse Anti-ABCA6 Recombinant Antibody (V2-178915) (CBMAB-A0150-YC)

Provided herein is a Mouse monoclonal antibody against Mouse ATP Binding Cassette Subfamily A Member 6. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ABCA6 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
V2-178915
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Raised against amino acids 711-838 mapping within an internal region of ABCA6 of mouse origin
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
ELISA1:30-1:3,000
IF(ICC)1:50-1:500
IP1-2 µl per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ATP Binding Cassette Subfamily A Member 6
Introduction
ABCA6 belongs to the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, a
Entrez Gene ID
76184
UniProt ID
Q8K441
Alternative Names
ATP Binding Cassette Subfamily A Member 6; ATP-Binding Cassette, Sub-Family A (ABC1), Member 6; ATP-Binding Cassette Sub-Family A Member 6; ATP-Binding Cassette A6; ABC Transporter ABCA6; EC 2.5.1.19; EC 3.6.3.25; EST155051; EC 3.6.3;
Function
Probable transporter which may play a role in macrophage lipid transport and homeostasis.
Biological Process
Lipid transport
Cellular Location
Golgi apparatus membrane

Xu, J., Zhou, Y., Yang, Y., Lv, C., Liu, X., & Wang, Y. (2020). Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection. BMC immunology, 21, 1-11.

Huang, R., Yan, G., Sun, H., Zhang, J., Song, D., Kong, R., ... & Huang, Z. (2020). Identification of prognostic and metastasis-related alternative splicing signatures in hepatocellular carcinoma. Bioscience reports, 40(7), BSR20201001.

Breuss, M. W., Mamerto, A., Renner, T., & Waters, E. R. (2020). The Evolution of the Mammalian ABCA6-like Genes: Analysis of Phylogenetic, Expression, and Population Genetic Data Reveals Complex Evolutionary Histories. Genome biology and evolution, 12(11), 2093-2106.

Imperio, G. E., Javam, M., Lye, P., Constantinof, A., Dunk, C. E., Reis, F. M., ... & Bloise, E. (2019). Gestational age‐dependent gene expression profiling of ATP‐binding cassette transporters in the healthy human placenta. Journal of cellular and molecular medicine, 23(1), 610-618.

Briz, O., Perez-Silva, L., Al-Abdulla, R., Abete, L., Reviejo, M., Romero, M. R., & Marin, J. J. (2019). What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugs. Expert opinion on drug metabolism & toxicology, 15(7), 577-593.

Tachikawa, M., Toki, H., Watanabe, M., Tomi, M., Hosoya, K. I., & Terasaki, T. (2018). Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels. Anatomical science international, 93(4), 456-463.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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