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Mouse Anti-ABCC3 Recombinant Antibody (V2-179015) (CBMAB-A0250-YC)

Provided herein is a Mouse monoclonal antibody against Human ATP Binding Cassette Subfamily C Member 3. The antibody can be used for immunoassay techniques, such as FC, ICC, IHC-Fr, WB.
See all ABCC3 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179015
Antibody Isotype
IgG2b
Application
FC, ICC, IHC-Fr, WB

Basic Information

Immunogen
A bacterial fusion protein of MRP3, containing aa 830-949 of the protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:10-1:200
IHC1:10-1:200
FC10-20 µl/10^6 cells
IF(ICC)1:10-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 830-949

Target

Full Name
ATP BINDING CASSETTE SUBFAMILY C MEMBER 3
Introduction
ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN
Entrez Gene ID
UniProt ID
Alternative Names
ATP Binding Cassette Subfamily C Member 3; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3; Canalicular Multispecific Organic Anion Transporter 2; Multi-Specific Organic Anion Transporter D; ATP-Binding Cassette Sub-Family C Member 3; Multidrug Re
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells.
Biological Process
Bile acid and bile salt transport
Canalicular bile acid transport
Drug transmembrane transport
Leukotriene transport
Transmembrane transport
Transport across blood-brain barrier
Xenobiotic transport
Cellular Location
Basolateral cell membrane
Topology
Extracellular: 1-32 aa
Helical: 33-53 aa
Cytoplasmic: 54-73 aa
Helical: 74-94 aa
Extracellular: 95-99 aa
Helical: 100-120 aa
Cytoplasmic: 121-132 aa
Helical: 133-153 aa
Extracellular: 154-171 aa
Helical: 172-192 aa
Cytoplasmic: 193-302 aa
Helical: 303-323 aa
Extracellular: 324-349 aa
Helical: 350-370 aa
Cytoplasmic: 371-426 aa
Helical: 427-447 aa
Extracellular: 448-450 aa
Helical: 451-471 aa
Cytoplasmic: 472-533 aa
Helical: 534-554 aa
Extracellular: 555-576 aa
Helical: 577-597 aa
Cytoplasmic: 598-963 aa
Helical: 964-984 aa
Extracellular: 985-1021 aa
Helical: 1022-1042 aa
Cytoplasmic: 1043-1085 aa
Helical: 1086-1106 aa
Extracellular: 1107 aa
Helical: 1108-1128 aa
Cytoplasmic: 1129-1199 aa
Helical: 1200-1220 aa
Extracellular: 1221-1222 aa
Helical: 1223-1243 aa
Cytoplasmic: 1244-1527 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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