Mouse Anti-ABCD3 Recombinant Antibody (V2-6058) (CBMAB-0003CQ)

Name: Mouse Anti-ABCD3 Recombinant Antibody (V2-6058)
SKU: CBMAB-0003CQ
Rating: 5 (1 reviews)

See all ABCD3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-6058

Application

IF, IHC-P

Immunogen

Human PMP70 aa 410-474

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000
IHC	1:1,000
IF(ICC)	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.09% sodium azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ATP-binding cassette, sub-family D (ALD), member 3

Introduction

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. Mutation in ABCD3 have been found in two individuals affected by Zellweger syndrome. However, the role of ABCD3 in the causation of Zellweger syndrome remains uncertain. which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.

Entrez Gene ID

5825

UniProt ID

P28288

Alternative Names

ATP-Binding Cassette, Sub-Family D (ALD), Member 3; 70 KDa Peroxisomal Membrane Protein; PXMP1; PMP70; DJ824O18.1 (ATP-Binding Cassette, Sub-Family D (ALD), Member 3 (PMP70, PXMP1)); Peroxisomal Membrane Protein 1 (70kD, Zellweger Syndrome); Peroxisomal Membrane Protein-1 (70kD); ABC43; CBAS5; ZWS2

Function

Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity.

Biological Process

Fatty acid beta-oxidation
Fatty acid biosynthetic process
Lipid transport
Long-chain fatty acid import into peroxisome
Peroxisome organization
Protein import into peroxisome membrane
Response to drug
Response to organic cyclic compound
Very long-chain fatty acid catabolic process

Cellular Location

Peroxisome membrane

Involvement in disease

An autosomal recessive disorder characterized by hepatosplenomegaly, hepatic fibrosis, progressive liver failure, and accumulation of peroxisomal C27-bile acid intermediates in plasma.

Zhang, Y., Zhang, Y., Wang, J., Yang, J., & Yang, G. (2020). Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer. Oncology letters, 19(5), 3567-3577.

Tan, H. W. S., Anjum, B., Shen, H. M., Ghosh, S., Yen, P. M., & Sinha, R. A. (2019). Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy, 15(8), 1455-1459.

Okamoto, T., Kawaguchi, K., Watanabe, S., Agustina, R., Ikejima, T., Ikeda, K., ... & Imanaka, T. (2018). Characterization of human ATP-binding cassette protein subfamily D reconstituted into proteoliposomes. Biochemical and biophysical research communications, 496(4), 1122-1127.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-ABCD3 Recombinant Antibody (V2-6058)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-ABCD3 Recombinant Antibody (V2-179063) (CAT#: CBMAB-A0299-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry