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Mouse Anti-ABO Recombinant Antibody (V2-634041) (CBMAB-AP037LY)


See all ABO antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-634041
Antibody Isotype
IgM, κ
Application
IF, IHC

Basic Information

Immunogen
Mixture of erythrocytes of blood group A and glycoprotein fraction isolated from the saliva of secretors with blood group A
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1-2 µg/ml
IHC-P0.5-1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase
Introduction
This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
28
UniProt ID
P16442
Alternative Names
ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase; ABO Blood Group (Transferase A, Alpha 1-3-N-Acetylgalactosaminyltransferase; Transferase B, Alpha 1-3-Galactosyltransferase); NAGAT; Glycoprotein-Fucosylgalactoside Alpha-N-Acetylgalactosaminyltransferase; Fucosylglycoprotein Alpha-N-Acetylgalactosaminyltransferase; Glycoprotein-Fucosylgalactoside Alpha-Galactosyltransferase; Fucosylglycoprotein 3-Alpha-Galactosyltransferase; Histo-Blood Group ABO System Transferase; B(A) Alpha-1,3-Galactosyltransferase; Histo-Blood Group A2 Transferase;
Function
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Biological Process
Lipid glycosylation
Oligosaccharide biosynthetic process
Protein glycosylation
Cellular Location
Secreted; Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Topology
Cytoplasmic: 1-32 aa
Helical: 33-53 aa
Lumenal: 54-354 aa
PTM
The soluble form derives from the membrane form by proteolytic processing.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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