ABO

This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name
ABO, Alpha 1-3-N-Acetylgalactosaminyltransferase And Alpha 1-3-Galactosyltransferase
Function
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Biological Process
Lipid glycosylation
Oligosaccharide biosynthetic process
Protein glycosylation
Cellular Location
Secreted; Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Topology
Cytoplasmic: 1-32 aa
Helical: 33-53 aa
Lumenal: 54-354 aa
PTM
The soluble form derives from the membrane form by proteolytic processing.
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Anti-ABO antibodies

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Human Recombinant ABO protein, hFc Tag (V2LY-0526-LY1882)

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Target: ABO
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 63-354
Tag: hFc Tag
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-634043) (CBMAB-AP040LY)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: V2-634043
Application*: IF, IHC
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-634042) (CBMAB-AP038LY)

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Target: ABO
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-634042
Application*: IF, IHC
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-634041) (CBMAB-AP037LY)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: V2-634041
Application*: IF, IHC
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-634040) (CBMAB-AP034LY)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: V2-634040
Application*: IF, IHC
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179138) (CBMAB-A0381-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179138
Application*: WB, IH
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179137) (CBMAB-A0380-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: V2-179137
Application*: IH, P, Agg
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179133) (CBMAB-A0376-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: V2-179133
Application*: E
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179130) (CBMAB-A0373-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: V2-179130
Application*: WB, E
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179129) (CBMAB-A0372-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-179129
Application*: E, WB
Datasheet SDS

Mouse Anti-ABO Recombinant Antibody (V2-179128) (CBMAB-A0371-YC)

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Target: ABO
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: V2-179128
Application*: P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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