Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906)


See all ACKR3 antibodies
Online Inquiry
Tested Data
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in ELISA
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in ELISA
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in WB
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in WB
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in WB
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in WB
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IF
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IF
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in FC
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in FC
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IHC
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IHC
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IHC
Mouse Anti-ACKR3 Recombinant Antibody (CBT4137) (V2LY-0625-LY1906) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4137
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human CXCR7(AA: extra mix) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:50-1:200
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
57007
UniProt ID
P25106
Function
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding leads to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Biological Process
Angiogenesis
Calcium-mediated signaling
Cell adhesion
Cell chemotaxis
Chemokine-mediated signaling pathway
G protein-coupled receptor signaling pathway
Immune response
Negative regulation of cell population proliferation
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Positive regulation of cytosolic calcium ion concentration
Positive regulation of ERK1 and ERK2 cascade
Positive regulation of mesenchymal stem cell migration
Receptor internalization
Vasculogenesis
Viral process
Topology
Extracellular: 1-40 aa
Helical: 41-61 aa
Cytoplasmic: 62-81 aa
Helical: 82-102 aa
Extracellular: 103-118 aa
Helical: 119-139 aa
Cytoplasmic: 140-162 aa
Helical: 163-183 aa
Extracellular: 184-213 aa
Helical: 214-234 aa
Cytoplasmic: 235-252 aa
Helical: 253-273 aa
Extracellular: 274-296 aa
Helical: 297-319 aa
Cytoplasmic: 320-362 aa
PTM
The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ACKR3 Recombinant Antibody (CBT4137)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry