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Mouse Anti-ACP2 Recombinant Antibody (V2-610934) (CBMAB-A0077-LY)

The product is antibody recognizes ACP2. The antibody M1-4A12 immunoassay techniques such as: WB, ELISA.
See all ACP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-610934
Antibody Isotype
IgG2b, λ
Application
WB, ELISA

Basic Information

Immunogen
ACP2 (AAH03160, 1 a.a. ~ 423 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 µg/ml
IHC5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
acid phosphatase 2, lysosomal
Introduction
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
53
Biological Process
Dephosphorylation
Lysosome organization
Cellular Location
Lysosome membrane; Lysosome lumen. The soluble form arises by proteolytic processing of the membrane-bound form.
Topology
Lumenal: 31-380 aa
Helical: 381-401 aa
Cytoplasmic: 402-423 aa
PTM
The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.

Jiao, X., Rahimi Balaei, M., Abu-El-Rub, E., Casoni, F., Pezeshgi Modarres, H., Dhingra, S., ... & Marzban, H. (2021). Reduced Granule Cell Proliferation and Molecular Dysregulation in the Cerebellum of Lysosomal Acid Phosphatase 2 (ACP2) Mutant Mice. International journal of molecular sciences, 22(6), 2994.

Mehdizadeh, M., Ashtari, N., Jiao, X., Rahimi Balaei, M., Marzban, A., Qiyami-Hour, F., ... & Marzban, H. (2020). Alteration of the Dopamine Receptors’ Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked–Ataxia (NAX)) Mouse. International journal of molecular sciences, 21(8), 2914.

de Pizzol Júnior, J. P., Sasso-Cerri, E., & Cerri, P. S. (2018). Matrix metalloproteinase-1 and acid phosphatase in the degradation of the lamina propria of eruptive pathway of rat molars. Cells, 7(11), 206.

Lee, J., Kim, J., Son, K., d’Alexandry, A. L. P. H., & Min, J. Y. (2017). Acid phosphatase 2 (ACP2) is required for membrane fusion during influenza virus entry. Scientific reports, 7(1), 1-13.

Lee, Y. C., Su, C. Y., Lin, Y. F., Lin, C. M., Fang, C. Y., Lin, Y. K., ... & Chen, C. L. (2017). Lysosomal acid phosphatase 2 is an unfavorable prognostic factor but is associated with better survival in stage II colorectal cancer patients receiving chemotherapy. Oncotarget, 8(7), 12120.

Ashtari, N. (2017). Cerebellar corticogenesis in the lysosomal acid phosphatase (acp2) mutant mice: purkinje cell migration disorder.

Jiao, X. (2017). The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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