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Mouse Anti-ACSF3 Recombinant Antibody (V2-179441) (CBMAB-A0748-YC)

Provided herein is a Mouse monoclonal antibody against Human Acyl-CoA Synthetase Family Member 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ACSF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-179441
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Raised against amino acids 264-560 mapping near the C-terminus of ACSF3 of mouse origin
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Acyl-CoA Synthetase Family Member 3
Introduction
ACSF3 is a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malo
Entrez Gene ID
Human197322
Mouse257633
Rat498962
UniProt ID
HumanQ4G176
MouseQ3URE1
RatD3ZUX7
Alternative Names
Acyl-CoA Synthetase Family Member 3; Malonyl-CoA Synthetase; EC 6.2.1.-; EC 6.2.1;
Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Biological Process
Fatty acid biosynthetic process
Fatty acid metabolic process
Long-chain fatty-acyl-CoA biosynthetic process
Malonate catabolic process
Cellular Location
Mitochondrion
Involvement in disease
Combined malonic and methylmalonic aciduria (CMAMMA): A metabolic disease characterized by malonic and methylmalonic aciduria, with urinary excretion of much larger amounts of methylmalonic acid than malonic acid, in the presence of normal malonyl-CoA decarboxylase activity. Clinical features include coma, ketoacidosis, hypoglycemia, failure to thrive, microcephaly, dystonia, axial hypotonia and/or developmental delay, and neurologic manifestations including seizures, psychiatric disease and/or cognitive decline.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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