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Mouse Anti-ACTR5 Recombinant Antibody (V2-179663) (CBMAB-A1017-YC)

Provided herein is a Mouse monoclonal antibody against Human ARP5 Actin Related Protein 5 Homolog. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all ACTR5 antibodies
Published Data
Mouse Anti-ACTR5 Recombinant Antibody (F-12) (CBMAB-A1017-YC) in WB
Western blot of ACTR5, CDKN2A, and β-actin in dCas9-Krab-expressing HepG2 and U87 cells transduced with sgiNTC and sgiACTR5. ...View More
Xu, X., Chan, A. K., Li, M., Liu, Q., Mattson, N., Pangeni Pokharel, S., ... & Chen, C. W. (2022). ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science Advances, 8(51), eadc8911.
Mouse Anti-ACTR5 Recombinant Antibody (F-12) (CBMAB-A1017-YC) in WB
Western blot of ACTR5 and IES6 in the TST-purified WT- and ΔA5-ACTR5 protein complexes. ...View More
Xu, X., Chan, A. K., Li, M., Liu, Q., Mattson, N., Pangeni Pokharel, S., ... & Chen, C. W. (2022). ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science Advances, 8(51), eadc8911.
Mouse Anti-ACTR5 Recombinant Antibody (F-12) (CBMAB-A1017-YC) in WB
Western blot of IES6, ACTR5, CDKN2A, CDK6, Rb, p-Rb, E2F1, and β-actin in HepG2-dCas9-Krab cells transduced with sgiNTC and sgiIES6. ...View More
Xu, X., Chan, A. K., Li, M., Liu, Q., Mattson, N., Pangeni Pokharel, S., ... & Chen, C. W. (2022). ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner. Science Advances, 8(51), eadc8911.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-179663
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 39-71 near the N-terminus of ACTR5 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ARP5 Actin Related Protein 5 Homolog
Introduction
ACTR5 is a proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. ACTR5 is involved in DNA double-strand break repair and UV-damage excision repair.
Entrez Gene ID
79913
UniProt ID
Q9H9F9
Alternative Names
ARP5 Actin Related Protein 5 Homolog; Sarcoma Antigen NY-SAR-16; INO80 Complex Subunit M; HARP5; Arp5; ARP5 (Actin-Related Protein 5, Yeast) Homolog; ARP5 Actin-Related Protein 5 Homolog (Yeast); Actin-Related Protein 5; INO80M;
Function
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.
Biological Process
ATP-dependent chromatin remodeling
DNA recombination
Double-strand break repair
Protein deubiquitination
Regulation of transcription, DNA-templated
UV-damage excision repair
Cellular Location
Cytoplasm; Nucleus. Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling. Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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