Sign in or Register   Sign in or Register
  |  

Rabbit Anti-ACVR2B Recombinant Antibody (V2-179694) (CBMAB-A1053-YC)

Provided herein is a Rabbit monoclonal antibody against Mouse Activin A Receptor Type 2B. The antibody can be used for immunoassay techniques, such as ELISA.
See all ACVR2B antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
V2-179694
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse ACVR2B protein
Host Species
Rabbit
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
activin A receptor, type IIB
Introduction
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which i
Entrez Gene ID
11481
UniProt ID
P27040
Alternative Names
Activin A Receptor Type 2B; Activin A Receptor, Type IIB; EC 2.7.11.30; ActR-IIB; Activin Receptor Type IIB; Activin Receptor Type-2B; EC 2.7.11; ACTRIIB; HTX4;
Function
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Biological Process
Activin receptor signaling pathway
Anterior/posterior pattern specification
Artery development
Blood vessel remodeling
BMP signaling pathway
Cellular response to growth factor stimulus
Lymphangiogenesis
Lymphatic endothelial cell differentiation
Negative regulation of BMP signaling pathway
Negative regulation of cold-induced thermogenesis
Negative regulation of transcription by RNA polymerase II
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of osteoblast differentiation
Protein phosphorylation
Regulation of transcription, DNA-templated
Retina vasculature development in camera-type eye
Signal transduction
Transmembrane receptor protein serine/threonine kinase signaling pathway
Venous blood vessel development
Cellular Location
Cell membrane
Involvement in disease
Heterotaxy, visceral, 4, autosomal (HTX4): A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can be associated with a variety of congenital defects including cardiac malformations. HTX4 clinical features include dextrocardia, right aortic arch and a right-sided spleen, anomalies of the inferior and the superior vena cava, atrial ventricular canal defect with dextro-transposed great arteries, pulmonary stenosis, polysplenia and midline liver.
Topology
Extracellular: 19-137 aa
Helical: 138-158 aa
Cytoplasmic: 159-512 aa
PTM
Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity.

O'Sullivan, M. P., Denihan, N., Sikora, K., Finder, M., Ahearne, C., Clarke, G., ... & Murray, D. M. (2021). Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic–Ischemic Encephalopathy. Neuropediatrics.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Lautaoja, J. H., Lalowski, M., Nissinen, T. A., Hentilä, J., Shi, Y., Ritvos, O., ... & Hulmi, J. J. (2019). Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade. American Journal of Physiology-Endocrinology And Metabolism, 316(5), E852-E865.

O’Connell, T. M., Pin, F., Couch, M. E., & Bonetto, A. (2019). Treatment with soluble activin receptor type IIB alters metabolic response in chemotherapy-induced cachexia. Cancers, 11(9), 1222.

Gao, X., Zhao, P., Hu, J., Zhu, H., Zhang, J., Zhou, Z., ... & Tang, F. (2018). Micro RNA‐194 protects against chronic hepatitis B‐related liver damage by promoting hepatocyte growth via ACVR 2B. Journal of cellular and molecular medicine, 22(9), 4534-4544.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-ACVR2B Recombinant Antibody (V2-179694)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare