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Mouse Anti-ADAMTS15 Recombinant Antibody (V2-179834) (CBMAB-A1197-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15. The antibody can be used for immunoassay techniques, such as WB, FC, IHC, CyTOF.
See all ADAMTS15 antibodies
Published Data
Mouse Anti-ADAMTS15 Recombinant Antibody (561819) (CBMAB-A1197-YC) in FC
Histograms from FACS analysis of differentiating pluripotent stem cells using the indicated antibodies. PAX7-expressing cells (GFP+; red line) are compared to control cells (GFP-; black line). ...View More
Magli, A., Incitti, T., Kiley, J., Swanson, S. A., Darabi, R., Rinaldi, F., ... & Perlingeiro, R. C. (2017). PAX7 targets, CD54, integrin α9β1, and SDC2, allow isolation of human ESC/iPSC-derived myogenic progenitors. Cell reports, 19(13), 2867-2877.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179834
Antibody Isotype
IgG2b
Application
WB, IHC-F, IHC, MC

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ADAMTS15, Gly18-Cys682.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 15
Introduction
ADAMTS15 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like
Entrez Gene ID
170689
UniProt ID
Q8TE58
Alternative Names
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 15; ADAM-TS 15; ADAM-TS15; ADAMTS-15; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 15, Preproprotein; A Disintegrin-Like And Metalloprotease (Reprolysin T
Function
Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
Biological Process
Extracellular matrix disassembly
Extracellular matrix organization
Myoblast fusion
Cellular Location
Extracellular matrix; Cell surface
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. Also N-glycosylated. These other glycosylations can also facilitate secretion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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