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Mouse Anti-ADAMTS17 Recombinant Antibody (V2-179836) (CBMAB-A1199-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all ADAMTS17 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
V2-179836
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Human ADAMTS17 (NP_620688, 543-651 aa) partial recombinant protein with GST tag
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P1.2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 543-651

Target

Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 17
Introduction
ADAMTS17 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like
Entrez Gene ID
Human170691
Mouse233332
UniProt ID
HumanQ8TE56
MouseD3YX90
Alternative Names
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 17; EC 3.4.24.82; EC 3.4.24.80; EC 3.4.24.-; ADAM-TS 17; ADAM-TS17; ADAMTS-17; EC 3.4.24;
Biological Process
Extracellular matrix organization
Cellular Location
Extracellular matrix
Involvement in disease
Weill-Marchesani syndrome 4 (WMS4): An autosomal recessive syndrome characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. Brachydactyly and decreased joint flexibility are present in some patients.
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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