Sign in or Register   Sign in or Register
  |  

Mouse Anti-ADAMTS2 Recombinant Antibody (V2-179838) (CBMAB-A1201-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ADAMTS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
V2-179838
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa1112-1210 from ADAMTS2 (NM_014244, NP_055059) with GST tag.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2
Introduction
ADAMTS2 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like
Entrez Gene ID
Human9509
Rat287899
UniProt ID
HumanO95450
RatD3ZTE7
Alternative Names
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2; Procollagen N-Endopeptidase; Procollagen I N-Proteinase; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 2; Procollagen I/II Amino Propeptide-Processing E
Function
Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
Biological Process
Collagen catabolic process
Collagen fibril organization
Extracellular matrix organization
Lung development
Protein processing
Skin development
Spermatogenesis
Cellular Location
Extracellular matrix
Involvement in disease
Ehlers-Danlos syndrome, dermatosparaxis type (EDSDERMS): A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. EDSDERMS is an autosomal recessive form characterized by extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers. Joint hypermobility becomes more important with age.
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ADAMTS2 Recombinant Antibody (V2-179838)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare