Sign in or Register   Sign in or Register
  |  

Mouse Anti-ADAMTSL4 Recombinant Antibody (V2-179860) (CBMAB-A1230-YC)

Provided herein is a Mouse monoclonal antibody against Human ADAMTS Like 4. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ADAMTSL4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179860
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
ADAMTSL4 (AAH27478. 2, 1-424 aa) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAMTS-like 4
Introduction
ADAMTSL4 belongs to ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse bio
Entrez Gene ID
UniProt ID
Alternative Names
ADAMTS Like 4; Thrombospondin Repeat-Containing Protein 1; ADAMTSL-4; TSRC1; Thrombospondin Repeat Containing 1; ADAMTS-Like Protein 4; ECTOL2;
Function
Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.
Biological Process
Apoptotic process
Epithelial cell development
Extracellular matrix organization
Positive regulation of apoptotic process
Cellular Location
Extracellular matrix. Colocalizes with FMN1 microfibrils in the eye ECM.
Involvement in disease
Ectopia lentis 2, isolated, autosomal recessive (ECTOL2): An ocular abnormality characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation.
Ectopia lentis et pupillae (ECTOLP): An ocular abnormality characterized by displacement of the lenses and the pupils, associated with other ocular anomalies, but without systemic manifestations. The condition is usually bilateral, with the lenses and pupils displaced in opposite directions. Additional signs include enlarged corneal diameter, increased corneal astigmatism, increased anterior chamber depth, thinning and flattening of the iris with loss of crypts, angle malformation caused by enlarged iris processes, persistent pupillary membrane, loss of zonular fibers, tilted disk, and increased axial length. Secondary manifestations include refractive errors, glaucoma, early cataract development, and retinal detachment. Membrane formation on the posterior aspect of the iris has been observed both in histologic sections and on ultrasound biomicroscopy.
PTM
N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion (By similarity).
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-ADAMTSL4 Recombinant Antibody (V2-179860)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare