Rabbit Anti-ADAP1 Recombinant Antibody (V2-12521) (CBMAB-1011-CN)

This product is a rabbit antibody that recognizes ADAP1 of human. The antibody EPR14285 can be used for immunoassay techniques such as: IF, IP, WB.
See all ADAP1 antibodies

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

V2-12521

Antibody Isotype

IgG

Application

IF, IP, WB

Basic Information

Immunogen

Synthetic peptide within Human Centaurin alpha 1 aa. 150-250.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:20,000
IF(ICC)	1:100
IP	1:20-1:40

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.2, 40% Glycerol, 0.05% BSA

Preservative

0.1% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ArfGAP With Dual PH Domains 1

Introduction

This is a GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Entrez Gene ID

Human	11033
Mouse	231821

UniProt ID

Human

O75689

Alternative Names

GCS1L; CENTA1; p42IP4

Function

GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Biological Process

Cell surface receptor signaling pathway
Regulation of GTPase activity

Cellular Location

Nucleus; Cytoplasm. Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

References

Duellberg, C., Auer, A., Canigova, N., Loibl, K., & Loose, M. (2021). In vitro reconstitution reveals phosphoinositides as cargo-release factors and activators of the ARF6 GAP ADAP1. Proceedings of the National Academy of Sciences, 118(1).

Szatmari, E. M., Moran, C., Cohen, S., Jacob, A., Parra-Bueno, P., Kamasawa, N., ... & Yasuda, R. (2021). ADAP1/Centaurin-α1 negatively regulates dendritic spine function and memory formation in the hippocampus. Eneuro, 8(1).

Van Duzer, A., Taniguchi, S., Elhance, A., Tsujikawa, T., & Oshimori, N. (2019). ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival. Life science alliance, 2(6).

Giguère, H., Dumont, A. A., Berthiaume, J., Oliveira, V., Laberge, G., & Auger-Messier, M. (2018). ADAP1 limits neonatal cardiomyocyte hypertrophy by reducing integrin cell surface expression. Scientific reports, 8(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ADAP1 Recombinant Antibody (V2-607125)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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