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Mouse Anti-Adenylyl CAP2 Recombinant Antibody (V2-634140) (CBMAB-AP158LY)

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-634140
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Pro317~Ile455
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclase Associated Actin Cytoskeleton Regulatory Protein 2
Introduction
This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Cyclase Associated Actin Cytoskeleton Regulatory Protein 2; CAP 2; CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast); CAP, Adenylate Cyclase-Associated Protein, 2; Adenylyl Cyclase-Associated Protein 2; 2810452G09Rik;
Function
May have a regulatory bifunctional role.
Biological Process
Activation of adenylate cyclase activity
cAMP-mediated signaling
Cell morphogenesis
Cytoskeleton organization
Establishment or maintenance of cell polarity
Regulation of adenylate cyclase activity
Signal transduction
Cellular Location
Cell membrane

Kepser, L. J., Khudayberdiev, S., Hinojosa, L. S., Macchi, C., Ruscica, M., Marcello, E., ... & Rust, M. B. (2021). Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts. Scientific reports, 11(1), 1-12.

Wan, Y., Qiu, S., Yin, L., Gao, X., Jiang, Y., Feng, S., & Tang, C. (2021). CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9. Journal of Gastrointestinal Oncology, 12(2), 268.

Schneider, F., Metz, I., Khudayberdiev, S., & Rust, M. B. (2021). Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons. Cells, 10(6), 1525.

Adachi, M., Masugi, Y., Yamazaki, K., Emoto, K., Kobayashi, Y., Tominaga, E., ... & Sakamoto, M. (2020). Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes. Japanese journal of clinical oncology, 50(6), 643-652.

Kepser, L. J. (2020). The Role of the Actin Regulator Cyclase-associated Protein 2 (CAP2) for Mammalian Skeletal Muscle Development (Doctoral dissertation, Philipps-Universität Marburg).

Saker, Z., Bahmad, H. F., Fares, Y., Al Najjar, Z., Saad, M., Harati, H., & Nabha, S. (2020). Prognostic impact of adenylyl cyclase-associated protein 2 (CAP2) in glioma: a clinicopathological study. Heliyon, 6(1), e03236.

Kepser, L. J., Damar, F., De Cicco, T., Chaponnier, C., Prószyński, T. J., Pagenstecher, A., & Rust, M. B. (2019). CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function. Proceedings of the National Academy of Sciences, 116(17), 8397-8402.

Aspit, L., Levitas, A., Etzion, S., Krymko, H., Slanovic, L., Zarivach, R., ... & Parvari, R. (2019). CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy. Journal of medical genetics, 56(4), 228-235.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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