Mouse Anti-AGAP1 Recombinant Antibody (V2-180154) (CBMAB-A1571-YC)

Provided herein is a Mouse monoclonal antibody against Human ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all AGAP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

V2-180154

Antibody Isotype

IgG2b, κ

Application

ELISA, WB

Basic Information

Immunogen

AGAP1 (NP_055729. 2, 672-781 aa) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

Introduction

AGAP1 is a member of an ADP-ribosylation factor GTPase-activating protein family involved in membrane trafficking and cytoskeleton dynamics. This gene functions as a direct regulator of the adaptor-related protein complex 3 on endosomes.

Entrez Gene ID

116987

UniProt ID

Q9UPQ3

Alternative Names

ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 1; GTP-Binding And GTPase-Activating Protein 1; Centaurin, Gamma 2; Cnt-G2; CENTG2; AGAP-1;

Function

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.

Biological Process

Protein transport

Cellular Location

Cytoplasm. Associates with the endocytic compartment.

PTM

Phosphorylated on tyrosines.

References

Tsutsumi, K., Nakamura, Y., Kitagawa, Y., Suzuki, Y., Shibagaki, Y., Hattori, S., & Ohta, Y. (2020). AGAP1 regulates subcellular localization of FilGAP and control cancer cell invasion. Biochemical and biophysical research communications, 522(3), 676-683.

Pacault, M., Nizon, M., Pichon, O., Vincent, M., Le Caignec, C., & Isidor, B. (2019). A de novo 2q37. 2 deletion encompassing AGAP1 and SH3BP4 in a patient with autism and intellectual disability. European journal of medical genetics, 62(12), 103586.

Roy, N. S., Luo, R., & Randazzo, P. A. (2017). Phosphoinositides and Kinesin 13 Family Member Kif2A Cooperatively Regulate Arf GTPase Activating Protein AGAP1. The FASEB Journal, 31, 765-7.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-AGAP1 Recombinant Antibody (V2-180155)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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