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Mouse Anti-AKIRIN2 Recombinant Antibody (V2-180446) (CBMAB-A1954-YC)

Provided herein is a Mouse monoclonal antibody against Human Akirin 2. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all AKIRIN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180446
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-204 from human C6orf166 (AAH00764) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Akirin 2
Introduction
AKIRIN2 is required for the innate immune response and is a downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. AKIRIN2 forms a complex with YWHAB that acts to repress transcription
Entrez Gene ID
55122
UniProt ID
Q53H80
Alternative Names
Akirin 2; C6orf166; Fourteen-Three-Three Beta Interactant 1; Chromosome 6 Open Reading Frame 166; DJ486L4.2; Akirin-2; FBI1;
Function
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity).
Biological Process
Embryo development ending in birth or egg hatching Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of endopeptidase activity Source: Ensembl
Positive regulation of innate immune response Source: GO_Central
Positive regulation of interleukin-6 production Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Nucleus

Artigas-Jerónimo, S., Villar, M., Estrada-Peña, A., Velázquez-Campoy, A., Alberdi, P., & de la Fuente, J. (2021). Function of cofactor Akirin2 in the regulation of gene expression in model human Caucasian neutrophil-like HL60 cells. Bioscience reports, 41(7), BSR20211120.

Peek, S. L., Bosch, P. J., Bahl, E., Iverson, B. J., Parida, M., Bais, P., ... & Weiner, J. A. (2021). p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2. bioRxiv.

Zeng, M., Qu, K., Hanif, Q., Liu, J., Zhang, J., Chen, N., ... & Lei, C. (2020). Distribution of the variant at AKIRIN2: c.* 188G> A in Chinese cattle. Animal Biotechnology, 1-5.

Li, Y., Cheng, G., Zhao, Y., Bai, C., Wang, S., Wu, K., ... & Tong, B. (2020). SNPs in AKIRIN2, TTN, EDG1 and MYBPC1 genes are associated with growth-related traits in Chinese Qinchuan cattle.

Bosch, P. J., Fuller, L. C., & Weiner, J. A. (2019). A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo. genesis, 57(5), e23286.

Leng, K., Xu, Y., Kang, P., Qin, W., Cai, H., Wang, H., ... & Cui, Y. (2019). Akirin2 is modulated by miR-490-3p and facilitates angiogenesis in cholangiocarcinoma through the IL-6/STAT3/VEGFA signaling pathway. Cell death & disease, 10(4), 1-15.

Anwar, S., Wulandari, A. S., Putra, W. P. B., & Said, S. (2019). The The favorable alleles of AKIRIN2: c.* 188G> A, EDG1: c.-312A> G and TTN: g. 231054C> T as candidate markers for high-marbling are very low in Bali cattle. Biodiversitas Journal of Biological Diversity, 20(4), 965-970.

Bosch, P. J., Fuller, L. C., & Weiner, J. A. (2018). An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression. Scientific reports, 8(1), 1-12.

Liu, X., Xia, Y., Tang, J., Ma, L., Li, C., Ma, P., & Mao, B. (2017). Dual roles of Akirin2 protein during Xenopus neural development. Journal of Biological Chemistry, 292(14), 5676-5684.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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