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Mouse Anti-ALPK3 Recombinant Antibody (4G4) (CBMAB-A0314-LY)

The product is antibody recognizes ALPK3. The antibody 4G4 immunoassay techniques such as: WB, ELISA.
See all ALPK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G4
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IHC, IF

Basic Information

Immunogen
ALPK3 (NP_065829, 1811 a.a. ~ 1906 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC3 µg/ml
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
alpha-kinase 3
Entrez Gene ID
57538
UniProt ID
Q96L96
Alternative Names
FLJ12881; FLJ21176; KIAA1330; MAK; MIDORI
Function
Involved in cardiomyocyte differentiation.
Biological Process
Cardiac muscle cell development Source: GO_Central
Heart development Source: HGNC-UCL
Cellular Location
Nucleus
Involvement in disease
Cardiomyopathy, familial hypertrophic 27 (CMH27): A form of hypertrophic cardiomyopathy, a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH27 is a severe, early-onset form with features of hypertrophic and dilated cardiomyopathy.

Lopes, L. R., Garcia-Hernández, S., Lorenzini, M., Futema, M., Chumakova, O., Zateyshchikov, D., ... & Elliott, P. M. (2021). Alpha-protein kinase 3 (ALPK3)-truncating variants are a cause of autosomal dominant hypertrophic cardiomyopathy. European Heart Journal.

Wang, L. (2021). The Role of Alpha Protein Kinase 3 in Cardiac Development and Function (Doctoral dissertation, UC San Diego).

Walsh, R., & Bezzina, C. R. (2021). ALPK3: a full spectrum cardiomyopathy gene?. European Heart Journal.

Jorholt, J., Formicheva, Y., Vershinina, T., Kiselev, A., Muravyev, A., Demchenko, E., ... & Kostareva, A. (2020). Two new cases of hypertrophic cardiomyopathy and skeletal muscle features associated with ALPK3 homozygous and compound heterozygous variants. Genes, 11(10), 1201.

Herkert, J. C., Verhagen, J. M., Yotti, R., Haghighi, A., Phelan, D. G., James, P. A., ... & van de Laar, I. M. (2020). Expanding the clinical and genetic spectrum of ALPK3 variants: Phenotypes identified in pediatric cardiomyopathy patients and adults with heterozygous variants. American Heart Journal, 225, 108-119.

Agarwal, R. (2020). Deciphering the Molecular Mechanisms of ALPK3 and FLNC Cardiomyopathy (Doctoral dissertation).

Cheawsamoot, C., Phokaew, C., Chetruengchai, W., Chantranuwat, P., Puwanant, S., Tongsima, S., ... & Shotelersuk, V. (2020). A Pathogenic Variant in ALPK3 Is Associated with an Autosomal Dominant Adult-onset Hypertrophic Cardiomyopathy. Circulation: Genomic and Precision Medicine, 13(6), e003127.

Al Senaidi, K., Joshi, N., Al‐Nabhani, M., Al‐Kasbi, G., Al Farqani, A., Al‐Thihli, K., & Al‐Maawali, A. (2019). Phenotypic spectrum of ALPK3‐related cardiomyopathy. American Journal of Medical Genetics Part A, 179(7), 1235-1240.

Jaouadi, H., Kraoua, L., Chaker, L., Atkinson, A., Delague, V., Levy, N., ... & Zaffran, S. (2018). Novel ALPK3 mutation in a Tunisian patient with pediatric cardiomyopathy and facio-thoraco-skeletal features. Journal of human genetics, 63(10), 1077-1082.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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