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Mouse Anti-ALX3 Recombinant Antibody (1F1) (CBMAB-A2471-YC)

Provided herein is a Mouse monoclonal antibody against Human ALX Homeobox 3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all ALX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F1
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
ALX3 AA 150-249 partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ALX Homeobox 3
Introduction
ALX3 is a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblast
Entrez Gene ID
257
UniProt ID
O95076
Alternative Names
ALX Homeobox 3; Proline-Rich Transcription Factor ALX3; Aristaless-Like Homeobox 3; Frontonasal Dysplasia; Homeobox Protein Aristaless-Like 3; FND1; FND;
Function
Transcriptional regulator with a possible role in patterning of mesoderm during development.
Biological Process
Embryonic cranial skeleton morphogenesis Source: InterPro
Embryonic forelimb morphogenesis Source: Ensembl
Embryonic hindlimb morphogenesis Source: Ensembl
Pattern specification process Source: Ensembl
Regulation of apoptotic process Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Frontonasal dysplasia 1 (FND1): The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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