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Mouse Anti-AMELX Recombinant Antibody (6G3) (CBMAB-A0336-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6G3
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
AMELX (NP_001133, 93 a.a. ~ 191 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
amelogenin (amelogenesis imperfecta 1, X-linked)
Introduction
This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Entrez Gene ID
265
UniProt ID
Q99217
Alternative Names
AIH1; ALGN; AMG; AMGL; AMGX
Function
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
Biological Process
Biomineral tissue development Source: BHF-UCL
Cell adhesion Source: BHF-UCL
Cellular protein metabolic process Source: Reactome
Chondrocyte differentiation Source: BHF-UCL
Enamel mineralization Source: BHF-UCL
Epithelial to mesenchymal transition Source: BHF-UCL
Odontogenesis of dentin-containing tooth Source: BHF-UCL
Osteoblast differentiation Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: BHF-UCL
Positive regulation of tooth mineralization Source: BHF-UCL
Post-translational protein modification Source: Reactome
Regulation of cell population proliferation Source: BHF-UCL
Response to calcium ion Source: Ensembl
Response to drug Source: Ensembl
Response to nutrient Source: Ensembl
Signal transduction Source: BHF-UCL
Tooth mineralization Source: BHF-UCL
Cellular Location
Extracellular matrix
Involvement in disease
Amelogenesis imperfecta 1E (AI1E): An X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
PTM
Phosphorylated by FAM20C in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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