Mouse Anti-AMELX Recombinant Antibody (6G3) (CBMAB-A0336-LY)

Name: Mouse Anti-AMELX Recombinant Antibody (6G3)
SKU: CBMAB-A0336-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6G3

Application

WB, ELISA

Immunogen

AMELX (NP_001133, 93 a.a. ~ 191 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

amelogenin (amelogenesis imperfecta 1, X-linked)

Introduction

This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

Entrez Gene ID

265

UniProt ID

Q99217

Alternative Names

AIH1; ALGN; AMG; AMGL; AMGX

Function

Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

Biological Process

Biomineral tissue development Source: BHF-UCL
Cell adhesion Source: BHF-UCL
Cellular protein metabolic process Source: Reactome
Chondrocyte differentiation Source: BHF-UCL
Enamel mineralization Source: BHF-UCL
Epithelial to mesenchymal transition Source: BHF-UCL
Odontogenesis of dentin-containing tooth Source: BHF-UCL
Osteoblast differentiation Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: BHF-UCL
Positive regulation of tooth mineralization Source: BHF-UCL
Post-translational protein modification Source: Reactome
Regulation of cell population proliferation Source: BHF-UCL
Response to calcium ion Source: Ensembl
Response to drug Source: Ensembl
Response to nutrient Source: Ensembl
Signal transduction Source: BHF-UCL
Tooth mineralization Source: BHF-UCL

Cellular Location

Extracellular matrix

Involvement in disease

Amelogenesis imperfecta 1E (AI1E): An X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.

PTM

Phosphorylated by FAM20C in vitro.

Duan, X., Yang, S., Zhang, H., Wu, J., Zhang, Y., Ji, D., ... & Boerkoel, C. F. (2019). A Novel AMELX mutation, its phenotypic features, and skewed X inactivation. Journal of dental research, 98(8), 870-878.

Kim, Y. J., Kim, Y. J., Kang, J., Shin, T. J., Hyun, H. K., Lee, S. H., ... & Kim, J. W. (2017). A novel AMELX mutation causes hypoplastic amelogenesis imperfecta. Archives of oral biology, 76, 61-65.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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