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Mouse Anti-AMN Recombinant Antibody (260808) (CBMAB-A2544-YC)

Provided herein is a Mouse monoclonal antibody against Human Amnion Associated Transmembrane Protein. The antibody can be used for immunoassay techniques, such as WB.
See all AMN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
260808
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Amnionless Val20-Ala358.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amnion Associated Transmembrane Protein
Introduction
AMN is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in
Entrez Gene ID
81693
UniProt ID
Q9BXJ7
Alternative Names
Amnion Associated Transmembrane Protein; Visceral Endoderm-Specific Type 1 Transmembrane Protein; Amnionless Homolog (Mouse); Amnionless Homolog; Protein Amnionless; Amnionless; PRO1028;
Function
Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed:14576052, PubMed:30523278, PubMed:29402915). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed:14576052, PubMed:29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052, PubMed:26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable).
Biological Process
Cobalamin metabolic process Source: Reactome
Cobalamin transport Source: UniProtKB
Excretion Source: Ensembl
Golgi to plasma membrane protein transport Source: UniProtKB
High-density lipoprotein particle clearance Source: Reactome
Multicellular organism development Source: UniProtKB-KW
Protein localization Source: GO_Central
Receptor-mediated endocytosis Source: UniProtKB
Cellular Location
Isoform 1: Endosome membrane; Apical cell membrane; Cell membrane; Coated pit
Soluble protein amnionless: Secreted
Involvement in disease
Imerslund-Grasbeck syndrome 2 (IGS2): A form of Imerslund-Grasbeck syndrome, a rare autosomal recessive disorder characterized by vitamin B12 deficiency commonly resulting in megaloblastic anemia, which is responsive to parenteral vitamin B12 therapy and appears in infancy or early childhood. Clinical manifestations include failure to thrive, infections and neurological damage. Mild proteinuria, with no signs of kidney disease, is present in about half of the patients.
Topology
Extracellular: 20-357 aa
Helical: 358-378 aa
Cytoplasmic: 379-453 aa
PTM
N-glycosylated.
A soluble form arises by proteolytic removal of the membrane anchor.
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For research use only. Not intended for any clinical use.

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