Mouse Anti-AMPD1 Recombinant Antibody (D7) (CBMAB-A2562-YC)

Name: Mouse Anti-AMPD1 Recombinant Antibody (D7)
SKU: CBMAB-A2562-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-AMPD1 Recombinant Antibody (D7) in WB

Western blots for AMPD3 and AMPD1 in TA muscles. ...View More

Rojek, K. O., Krzemień, J., Doleżyczek, H., Boguszewski, P. M., Kaczmarek, L., Konopka, W., ... & Prószyński, T. J. (2019). Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLoS biology, 17(5), e3000253.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 104-181 mapping near the N-terminus of AMPD1 of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:30-1:3,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Adenosine Monophosphate Deaminase 1

Introduction

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isofor

Entrez Gene ID

270

UniProt ID

P23109

Alternative Names

Adenosine Monophosphate Deaminase 1; Adenosine Monophosphate Deaminase 1 (Isoform M); Myoadenylate Deaminase; Skeletal Muscle AMPD; EC 3.5.4.6; Adenosine Monophosphate Deaminase-1 (Muscle); AMP Deaminase Isoform M;

Function

AMP deaminase plays a critical role in energy metabolism.

Biological Process

AMP metabolic process Source: GO_Central
IMP biosynthetic process Source: GO_Central
IMP salvage Source: UniProtKB-UniPathway
Purine-containing compound salvage Source: Reactome
Response to organic substance Source: Ensembl

Cellular Location

Cytosol

Involvement in disease

Myopathy due to myoadenylate deaminase deficiency (MMDD): A metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue.

Yu, S., Wang, G., Liao, J., & Chen, X. (2021). A functional mutation in the AMPD1 promoter region affects promoter activity and breast meat freshness in chicken. Animal Genetics, 52(1), 121-125.

Mamoor, S. (2020). Adenosine monophosphate deaminase 1 is differentially expressed in the lymph node and brain metastases of patients with metastatic breast cancer.

Leońska-Duniec, A., Maculewicz, E., Humińska-Lisowska, K., Maciejewska-Skrendo, A., Leźnicka, K., Cięszczyk, P., ... & Ficek, K. (2020). AMPD1 C34T polymorphism (RS17602729) is not associated with post-exercise changes of body weight, body composition, and biochemical parameters in Caucasian females. Genes, 11(5), 558.

Mugandani, S. C. (2019). Athletic performance enhancing ACE, ACTN3, AMPD1 genetic markers, fitness characteristics, c-reactive protein and uric acid of cricket, netball, rugby and soccer players: a review. Journal of Applied Sports Sciences, (1), 131-149.

Kawano, Y., Inada, Y., Sasano, T., Nishimura, N., Hata, H., & Matsuoka, M. (2018). The purine metabolic enzyme AMPD1 is a novel therapeutic target for multiple myeloma. Blood, 132, 5614.

Zha, T., & Wu, H. (2018). Expression of serum AMPD1 in thyroid carcinoma and its clinical significance. Experimental and therapeutic medicine, 15(4), 3357-3361.

Feng, A. F., Liu, Z. H., Zhou, S. L., Zhao, S. Y., Zhu, Y. X., & Wang, H. X. (2017). Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis. BMC cardiovascular disorders, 17(1), 1-9.

Rannou, F., Scotet, V., Marcorelles, P., Monnoyer, R., & Le Maréchal, C. (2017). Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency. Plos one, 12(11), e0187266.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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