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Mouse Anti-AMPD1 Recombinant Antibody (D7) (CBMAB-A2562-YC)

Provided herein is a Mouse monoclonal antibody against Human Adenosine Monophosphate Deaminase 1. The antibody can be used for immunoassay techniques, such as FC, IF, ICC, IHC-Fr.
See all AMPD1 antibodies
Published Data
Mouse Anti-AMPD1 Recombinant Antibody (D7) in WB
Western blots for AMPD3 and AMPD1 in TA muscles. ...View More
Rojek, K. O., Krzemień, J., Doleżyczek, H., Boguszewski, P. M., Kaczmarek, L., Konopka, W., ... & Prószyński, T. J. (2019). Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLoS biology, 17(5), e3000253.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
D7
Antibody Isotype
IgG1, λ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 104-181 mapping near the N-terminus of AMPD1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:30-1:3,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adenosine Monophosphate Deaminase 1
Introduction
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isofor
Entrez Gene ID
270
UniProt ID
P23109
Alternative Names
Adenosine Monophosphate Deaminase 1; Adenosine Monophosphate Deaminase 1 (Isoform M); Myoadenylate Deaminase; Skeletal Muscle AMPD; EC 3.5.4.6; Adenosine Monophosphate Deaminase-1 (Muscle); AMP Deaminase Isoform M;
Function
AMP deaminase plays a critical role in energy metabolism.
Biological Process
AMP metabolic process Source: GO_Central
IMP biosynthetic process Source: GO_Central
IMP salvage Source: UniProtKB-UniPathway
Purine-containing compound salvage Source: Reactome
Response to organic substance Source: Ensembl
Cellular Location
Cytosol
Involvement in disease
Myopathy due to myoadenylate deaminase deficiency (MMDD): A metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue.

Yu, S., Wang, G., Liao, J., & Chen, X. (2021). A functional mutation in the AMPD1 promoter region affects promoter activity and breast meat freshness in chicken. Animal Genetics, 52(1), 121-125.

Mamoor, S. (2020). Adenosine monophosphate deaminase 1 is differentially expressed in the lymph node and brain metastases of patients with metastatic breast cancer.

Leońska-Duniec, A., Maculewicz, E., Humińska-Lisowska, K., Maciejewska-Skrendo, A., Leźnicka, K., Cięszczyk, P., ... & Ficek, K. (2020). AMPD1 C34T polymorphism (RS17602729) is not associated with post-exercise changes of body weight, body composition, and biochemical parameters in Caucasian females. Genes, 11(5), 558.

Mugandani, S. C. (2019). Athletic performance enhancing ACE, ACTN3, AMPD1 genetic markers, fitness characteristics, c-reactive protein and uric acid of cricket, netball, rugby and soccer players: a review. Journal of Applied Sports Sciences, (1), 131-149.

Kawano, Y., Inada, Y., Sasano, T., Nishimura, N., Hata, H., & Matsuoka, M. (2018). The purine metabolic enzyme AMPD1 is a novel therapeutic target for multiple myeloma. Blood, 132, 5614.

Zha, T., & Wu, H. (2018). Expression of serum AMPD1 in thyroid carcinoma and its clinical significance. Experimental and therapeutic medicine, 15(4), 3357-3361.

Feng, A. F., Liu, Z. H., Zhou, S. L., Zhao, S. Y., Zhu, Y. X., & Wang, H. X. (2017). Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis. BMC cardiovascular disorders, 17(1), 1-9.

Rannou, F., Scotet, V., Marcorelles, P., Monnoyer, R., & Le Maréchal, C. (2017). Effects of AMPD1 common mutation on the metabolic-chronotropic relationship: Insights from patients with myoadenylate deaminase deficiency. Plos one, 12(11), e0187266.

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For research use only. Not intended for any clinical use.

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