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Mouse Anti-AMPD3 Recombinant Antibody (AMPD3/901) (CBMAB-AP309LY)


See all AMPD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
AMPD3/901
Antibody Isotype
IgG2b, κ
Application
IHC

Basic Information

Immunogen
Recombinant full-length human AMPD3 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC2-4 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adenosine Monophosphate Deaminase 3
Introduction
This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
272
UniProt ID
Q01432
Alternative Names
Adenosine Monophosphate Deaminase 3; EC 3.5.4.6; Adenosine Monophosphate Deaminase (Isoform E); Erythrocyte-Specific AMP Deaminase; Erythrocyte AMP Deaminase; AMP Deaminase Isoform E;
Function
AMP deaminase plays a critical role in energy metabolism.
Biological Process
AMP catabolic process Source: ProtInc
AMP metabolic process Source: GO_Central
IMP biosynthetic process Source: GO_Central
IMP salvage Source: UniProtKB-UniPathway
neutrophil degranulation Source: Reactome
purine-containing compound salvage Source: Reactome
Cellular Location
Cytosol; Extracellular region; Ficolin-1-rich granule lumen; Secretory granule lumen
Involvement in disease
Adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE): A metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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