Mouse Anti-PRKAB1 Recombinant Antibody (1A7-E11-E9) (CBMAB-A2582-YC)

Name: Mouse Anti-PRKAB1 Recombinant Antibody (1A7-E11-E9)
SKU: CBMAB-A2582-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1A7-E11-E9

Application

WB, ICC, IP, IHC

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PRKAB1

Introduction

AMPKB1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy

Entrez Gene ID

Human	5564
Mouse	19079
Rat	83803
Monkey	695737

UniProt ID

Human	Q9Y478
Mouse	Q9R078
Rat	P80386
Monkey	G7PIT4

Alternative Names

AMPK; HAMPKb; AU021155; 1300015D22Rik; E430008F22

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Biological Process

Cellular response to nutrient levelsManual Assertion Based On ExperimentIDA:ComplexPortal
Fatty acid biosynthetic processIEA:UniProtKB-KW
Nail developmentIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of catalytic activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytoplasm
cytosol
nucleoplasm
nucleotide-activated protein kinase complex
nucleus

PTM

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-PRKAB1 Recombinant Antibody (1A7-E11-E9) (CAT#: CBMAB-P2787-YC)

Antibody Pairs

PRKAB1 Matched Antibody Pair (927) (CAT#: APMAB-927LY)

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Rabbit Anti-PRKAB1 (Phosphorylated S108) Polyclonal Antibody (PTM-CBPAB-0178YC) (CAT#: PTM-CBPAB-0178YC)

Mouse Anti-PRKAB1 Recombinant Antibody (1A7-E11-E9) (CAT#: CBMAB-P2787-YC)

Mouse Anti-PRKAB1 Recombinant Antibody (3H12-1A10) (CAT#: CBMAB-P2789-YC)

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Rabbit Anti-PRKAB1 (Phosphorylated S181) Polyclonal Antibody (PTM-CBPAB-0180YC) (CAT#: PTM-CBPAB-0180YC)

PRKAB1 Matched Antibody Pair (927) (CAT#: APMAB-927LY)

Rabbit Anti-PRKAB1 (Phosphorylated S182) Polyclonal Antibody (PTM-CBPAB-0181YC) (CAT#: PTM-CBPAB-0181YC)

Recombinant Mouse Anti-PRKAB1 Antibody (CBAb196) (CAT#: CBMAB-Ab196-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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