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Mouse Anti-AP3B1 Recombinant Antibody (3B4) (CBMAB-A2986-YC)

Provided herein is a Mouse monoclonal antibody against Human Adaptor Related Protein Complex 3 Beta 1 Subunit. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all AP3B1 antibodies
Published Data
Fig.1 IC-HAdV induce MoDC maturationthrough DNA sensors TLR9.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa995-1095 from AP3B1 (NP_003655) with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
adaptor-related protein complex 3, beta 1 subunit
Introduction
AP3B1 is a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clat
Entrez Gene ID
8546
UniProt ID
O00203
Alternative Names
Adaptor Related Protein Complex 3 Beta 1 Subunit; Clathrin Assembly Protein Complex 3 Beta-1 Large Chain; Adaptor-Related Protein Complex 3 Subunit Beta-1; Adaptor Protein Complex AP-3 Subunit Beta-1; Beta-3A-Adaptin; ADTB3A; Adaptor-Related Protein Compl
Function
Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Biological Process
Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: Ensembl
Blood coagulation Source: Ensembl
Cell morphogenesis Source: Ensembl
Cellular protein modification process Source: Ensembl
Cellular zinc ion homeostasis Source: Ensembl
Establishment of protein localization to mitochondrial membrane involved in mitochondrial fission Source: Ensembl
Granulocyte differentiation Source: Ensembl
Hematopoietic progenitor cell differentiation Source: Ensembl
Homeostasis of number of cells Source: Ensembl
Inflammatory response Source: Ensembl
Intracellular protein transport Source: ProtInc
Lung morphogenesis Source: Ensembl
Lysosome organization Source: Ensembl
Melanosome organization Source: UniProtKB
mRNA transcription by RNA polymerase II Source: Ensembl
Platelet dense granule organization Source: Ensembl
Positive regulation of NK T cell differentiation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Protein localization to cell surface Source: Ensembl
Protein targeting to lysosome Source: Ensembl
Regulation of catalytic activity Source: Ensembl
Respiratory system process Source: Ensembl
Single fertilization Source: Ensembl
Skin epidermis development Source: Ensembl
Spermatogenesis Source: Ensembl
Synaptic vesicle budding from endosome Source: Ensembl
Toll-like receptor signaling pathway Source: Ensembl
Vesicle-mediated transport Source: GO_Central
Cellular Location
Golgi apparatus; Clathrin-coated vesicle membrane. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Involvement in disease
Hermansky-Pudlak syndrome 2 (HPS2): A form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. HPS2 differs from the other forms of HPS in that it includes immunodeficiency in its phenotype and patients with HPS2 have an increased susceptibility to infections.
PTM
Phosphorylated on serine residues.
Pyrophosphorylation by 5-diphosphoinositol pentakisphosphate (5-IP7) impairs interaction with KIF3A (PubMed:19934039). Serine pyrophosphorylation is achieved by Mg2+-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue (PubMed:19934039).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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