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Mouse Anti-AP4B1 Recombinant Antibody (1B2) (CBMAB-A2993-YC)

Provided herein is a Mouse monoclonal antibody against Human Adaptor Related Protein Complex 4 Beta 1 Subunit. The antibody can be used for immunoassay techniques, such as ELISA.
See all AP4B1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B2
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
AP4B1 (NP_006585, 640-740 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
adaptor-related protein complex 4, beta 1 subunit
Introduction
AP4B1 is a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (C
Entrez Gene ID
10717
UniProt ID
Q9Y6B7
Alternative Names
Adaptor Related Protein Complex 4 Beta 1 Subunit; AP-4 Adaptor Complex Subunit Beta; AP-4 Complex Subunit Beta-1; Beta 4 Subunit Of AP-4; Spastic Paraplegia 47; Beta4-Adaptin; Adaptor-Related Protein Complex 4, Beta 1 Subunit;
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Biological Process
Post-Golgi vesicle-mediated transport Source: Reactome
Protein localization Source: UniProtKB
Protein targeting Source: UniProtKB
Vesicle-mediated transport Source: GO_Central
Cellular Location
Trans-Golgi network membrane
Involvement in disease
Spastic paraplegia 47, autosomal recessive (SPG47): A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG47 is characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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