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Mouse Anti-ARHGEF26 Recombinant Antibody (CBXS-2188) (CBMAB-S4950-CQ)

This product is a mouse antibody that recognizes ARHGEF26. The antibody CBXS-2188 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all ARHGEF26 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2188
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 849-870 at the C-terminus of SGEF of human origin.
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Rho Guanine Nucleotide Exchange Factor 26
Introduction
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
Human26084
Mouse622434
Rat310460
UniProt ID
HumanQ96DR7
MouseD3YYY8
RatQ00238
Alternative Names
Rho Guanine Nucleotide Exchange Factor 26; Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor; Rho Guanine Nucleotide Exchange Factor (GEF) 26; SH3 Domain-Containing Guanine Exchange Factor; SGEF; Testicular Tissue Protein Li 171; HMFN1864; CSGEF;
Function
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
Biological Process
Activation of GTPase activity Source: GO_Central
Endothelial cell morphogenesis Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Positive regulation of apoptotic process Source: Reactome
Regulation of small GTPase mediated signal transduction Source: Reactome
Ruffle assembly Source: Ensembl
Cellular Location
Ruffle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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