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Mouse Anti-ARV1 Recombinant Antibody (4G12) (CBMAB-A0507-LY)

The product is antibody recognizes ARV1. The antibody 4G12 immunoassay techniques such as: WB, ELISA.
See all ARV1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
4G12
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
ARV1 (NP_073623.1, 1 a.a. ~ 271 a.a) full-length recombinant protein with GST tag.
Specificity
Human, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ARV1 Homolog, Fatty Acid Homeostasis Modulator
Entrez Gene ID
Human64801
Rat292097
UniProt ID
HumanQ9H2C2
RatD3ZTJ1
Function
Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892).
Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).
Biological Process
Cholesterol biosynthetic process Source: Reactome
Intracellular sterol transport Source: GO_Central
Regulation of cholesterol metabolic process Source: UniProtKB
Regulation of intracellular cholesterol transport Source: UniProtKB
Regulation of plasma membrane sterol distribution Source: GO_Central
Sphingolipid metabolic process Source: GO_Central
Sterol metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Developmental and epileptic encephalopathy 38 (DEE38): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE38 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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