Mouse Anti-ARV1 Recombinant Antibody (4G12) (CBMAB-A0507-LY)

Name: Mouse Anti-ARV1 Recombinant Antibody (4G12)
SKU: CBMAB-A0507-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4G12

Application

WB, ELISA

Immunogen

ARV1 (NP_073623.1, 1 a.a. ~ 271 a.a) full-length recombinant protein with GST tag.

Specificity

Human, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ARV1 Homolog, Fatty Acid Homeostasis Modulator

Entrez Gene ID

Human	64801
Rat	292097

UniProt ID

Human	Q9H2C2
Rat	D3ZTJ1

Function

Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892).
Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892).

Biological Process

Cholesterol biosynthetic process Source: Reactome
Intracellular sterol transport Source: GO_Central
Regulation of cholesterol metabolic process Source: UniProtKB
Regulation of intracellular cholesterol transport Source: UniProtKB
Regulation of plasma membrane sterol distribution Source: GO_Central
Sphingolipid metabolic process Source: GO_Central
Sterol metabolic process Source: GO_Central

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Developmental and epileptic encephalopathy 38 (DEE38): A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE38 inheritance is autosomal recessive.

Salian, S., Scala, M., Nguyen, T. T. M., Severino, M., Accogli, A., Amadori, E., ... & Campeau, P. M. (2021). Epileptic encephalopathy caused by ARV1 deficiency: refinement of the genotype–phenotype spectrum and functional impact on GPI‐anchored proteins. Clinical Genetics.

Davids, M., Menezes, M., Guo, Y., McLean, S. D., Hakonarson, H., Collins, F., ... & Malicdan, M. C. V. (2020). Homozygous splice-variants in human ARV1 cause GPI-anchor synthesis deficiency. Molecular genetics and metabolism, 130(1), 49-57.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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