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Mouse Anti-ASB10 Recombinant Antibody (1F3) (CBMAB-A0521-LY)

The product is antibody recognizes ASB10. The antibody 1F3 immunoassay techniques such as: WB, ELISA.
See all ASB10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1F3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
ASB10 (NP_001135931, 48 a.a. ~ 153 a.a) partial recombinant protein with GST tag.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ankyrin repeat and SOCS box-containing 10
Introduction
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq]
Entrez Gene ID
Human136371
Mouse117590
Rat499972
UniProt ID
HumanQ8WXI3
MouseQ91ZT7
RatB5DEZ7
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Nucleus; Cytoplasm. In the ciliary body, it is detected in the cytoplasm and perinuclear region of the pigmented ciliary epithelial layer. In the retina, it is detected in the nuclei of retinal ganglion cells.
Involvement in disease
Glaucoma 1, open angle, F (GLC1F): A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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