Mouse Anti-ASB8 Recombinant Antibody (1H1) (CBMAB-A0528-LY)

The product is antibody recognizes ASB8. The antibody 1H1 immunoassay techniques such as: IHC, ELISA.
See all ASB8 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1H1

Antibody Isotype

IgG2a, κ

Application

IHC, ELISA

Basic Information

Immunogen

ASB8 (NP_077000, 179 a.a. ~ 288 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

ankyrin repeat and SOCS box-containing 8

Entrez Gene ID

140461

UniProt ID

Q9H765

Alternative Names

FLJ21255; MGC5540; PP14212

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Biological Process

Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway

Cellular Location

Cytoplasm

References

Mo, J. S., & Chae, S. C. (2021). MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in colorectal cancer cells. Genes & Genomics, 43(1), 33-41.

Guo, Y., Li, R., Tan, Z., Shi, J., Fu, Y., Song, Y., ... & Huang, J. (2020). E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis. Molecular immunology, 121, 195-203.

Li, R., Chen, C., He, J., Zhang, L., Zhang, L., Guo, Y., ... & Huang, J. (2019). E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase. Virology, 532, 55-68.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
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Second antibody and isotype control

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