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  • Mouse Anti-ASB8 Recombinant Antibody (1H1)

Mouse Anti-ASB8 Recombinant Antibody (1H1) (CBMAB-A0528-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
1H1
Application
IHC, ELISA
Immunogen
ASB8 (NP_077000, 179 a.a. ~ 288 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
ankyrin repeat and SOCS box-containing 8
Entrez Gene ID
140461
UniProt ID
Q9H765
Alternative Names
FLJ21255; MGC5540; PP14212
Function
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Intracellular signal transduction Source: InterPro
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB-UniPathway
Cellular Location
Cytoplasm

Mo, J. S., & Chae, S. C. (2021). MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in colorectal cancer cells. Genes & Genomics, 43(1), 33-41.

Guo, Y., Li, R., Tan, Z., Shi, J., Fu, Y., Song, Y., ... & Huang, J. (2020). E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis. Molecular immunology, 121, 195-203.

Li, R., Chen, C., He, J., Zhang, L., Zhang, L., Guo, Y., ... & Huang, J. (2019). E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase. Virology, 532, 55-68.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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