Mouse Anti-ASCC2 Recombinant Antibody (3B2) (CBMAB-A0530-LY)

Name: Mouse Anti-ASCC2 Recombinant Antibody (3B2)
SKU: CBMAB-A0530-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3B2

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

ASCC2 (NP_115580, 672 a.a. ~ 757 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

activating signal cointegrator 1 complex subunit 2

Entrez Gene ID

84164

UniProt ID

Q9H1I8

Alternative Names

ASC1p100

Function

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457).
Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).

Biological Process

DNA dealkylation involved in DNA repair Source: Reactome
Regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Nucleus; Nucleus speckle. Colocalizes with the spliceosomal components PRPF8 and SNRNP200/BRR2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. Colocalizes with RNF113A and 'Lys-63'-linked polyubiquitinated proteins, ALKBH3 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage.

More Infomation

References

Jia, J., Absmeier, E., Holton, N., Pietrzyk-Brzezinska, A. J., Hackert, P., Bohnsack, K. E., ... & Wahl, M. C. (2020). The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Nature communications, 11(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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