Mouse Anti-ASPRV1 Recombinant Antibody (4H8) (CBMAB-A0549-LY)

The product is antibody recognizes ASPRV1. The antibody 4H8 immunoassay techniques such as: WB, ELISA.
See all ASPRV1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4H8

Antibody Isotype

IgG1, κ

Application

WB, ELISA

Basic Information

Immunogen

ASPRV1 (AAH31997.1, 1 a.a. ~ 152 a.a) full-length recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

aspartic peptidase, retroviral-like 1

Entrez Gene ID

151516

UniProt ID

Q53RT3

Alternative Names

MUNO; SASP; SASPase; Taps

Function

Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization.

Biological Process

Protein processing Source: UniProtKB
Skin development Source: UniProtKB

Cellular Location

Membrane

Involvement in disease

Ichthyosis, lamellar, autosomal dominant (ADLI): An autosomal dominant form of ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling. ADLI is characterized by onset at birth or within the first months of life, skin scaling on the entire body with relative sparing of face, anterior chest, and abdomen, and palmoplantar keratoderma. Patients may manifest mild erythema and moderate pruritus.

Topology

Cytoplasmic: 1-55 aa
Helical: 56-76 aa
Extracellular: 77-343 aa

PTM

Undergoes autocleavage which is necessary for activation of the protein.

References

Boyden, L. M., Zhou, J., Hu, R., Zaki, T., Loring, E., Scott, J., ... & Choate, K. A. (2020). Mutations in ASPRV1 Cause Dominantly Inherited Ichthyosis. The American Journal of Human Genetics, 107(1), 158-163.

Dietschi, E., Bauer, A., Jagannathan, V., Leeb, T., Waluk, D. P., Galichet, A., ... & Roosje, P. (2017). A de novo variant in the ASPRV1 gene in a dog with ichthyosis. PLoS Genetics, 13(3).

Hawkins, R. F. W., Patenaude, A., Dumas, A., Jain, R., Tesfagiorgis, Y., Kerfoot, S., ... & Vallières, L. (2017). ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis. JCI insight, 2(23).

Bauer, A., Waluk, D. P., Galichet, A., Timm, K., Jagannathan, V., Sayar, B. S., ... & Leeb, T. (2017). A de novo variant in the ASPRV1 gene in a dog with ichthyosis. PLoS genetics, 13(3), e1006651.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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