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Rabbit Anti-Asymmetric Dimethyl-SMARCC1 (Arg1064) Recombinant Antibody (D8I3U) (CBMAB-CP2506-LY)

The product is antibody recognizes Asymmetric Dimethyl-SMARCC1 (Arg1064). The antibody D8I3U immunoassay techniques such as: WB,IP,IHC-P.
See all Asymmetric Dimethyl-SMARCC1 (Arg1064) antibodies
Published Data
Rabbit Anti-Asymmetric Dimethyl-SMARCC1 (Arg1064) Recombinant Antibody (D8I3U) (CBMAB-CP2506-LY) in WB
Representative Western blots for MMA, unmethylated form of SmB (SmBme0), PRMT1, PRMT5, PRMT6, and PRMT7 in the TA muscles from WT and mKO mice. The ponceau stain demonstrates equal loading while approximate MWs are to the right of each image. ...View More
Stouth, D. W., Hartel, N. G., Vasam, G., Ng, S. Y., Webb, E. K., Rebalka, I. A., ... & Ljubicic, V. (2022). The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. Molecular Metabolism, 64, 101555.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8I3U
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Immunogen
Synthetic asymmetric dimethylpeptide corresponding to residues surrounding Arg1064 of human SMARCC1/BAF155 protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IHC-P1:800
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
Introduction
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.
Entrez Gene ID
Human6599
Mouse20588
Rat301020
Monkey711134
UniProt ID
HumanQ92922
MouseP97496
RatD3ZJU5
MonkeyF7HJG9
Alternative Names
Rsc8; SRG3; SWI3; BAF155; CRACC1
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207, PubMed:29374058).
Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Biological Process
Animal organ morphogenesis Source: Ensembl
ATP-dependent chromatin remodeling Source: UniProtKB
Chromatin remodeling Source: UniProtKB
Insulin receptor signaling pathway Source: Ensembl
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
Nervous system development Source: UniProtKB-KW
Nucleosome disassembly Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Prostate gland development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: BHF-UCL
Cellular Location
Nucleus; Cytoplasm
PTM
Phosphorylated on undefined residues at the G2/M transition by ERK1 and other kinases. This may contribute to cell cycle specific inactivation of remodeling complexes containing the phosphorylated protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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