Mouse Anti-ATCAY Recombinant Antibody (CBLNA-119) (CBMAB-1156-CN)

Name: Mouse Anti-ATCAY Recombinant Antibody (CBLNA-119)
SKU: CBMAB-1156-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLNA-119

Application

WB, ELISA

Immunogen

Partial recombinant (aa. 3-69) from human ATCAY (NP_149053) with GST tag.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Localized in aa. 3-69

More Infomation

Target

Full Name

ataxia, cerebellar, Cayman type

Introduction

This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic moleculesThis protein functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. The protein may play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, it may regulate the localization of mitochondria within axons and dendrites.

Entrez Gene ID

85300

UniProt ID

Q86WG3

Alternative Names

CLAC; BNIP-H

Function

Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.

Biological Process

Apoptotic process Source: GO_Central
Mitochondrion distribution Source: UniProtKB
Negative regulation of glutamate metabolic process Source: UniProtKB
Neuron projection development Source: UniProtKB
Polyphosphate catabolic process Source: GO_Central
Regulation of protein localization Source: UniProtKB

Cellular Location

Cytoplasm; Mitochondrion; Axon; Dendrite; Presynapse; Growth cone

Involvement in disease

Cerebellar ataxia, cayman type (ATCAY): Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood.

PTM

Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2.

Hales, E. N., Esparza, C., Peng, S., Dahlgren, A. R., Peterson, J. M., Miller, A. D., & Finno, C. J. (2020). Genome-wide association study and subsequent exclusion of ATCAY as a candidate gene involved in equine neuroaxonal dystrophy using two animal models. Genes, 11(1), 82.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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