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Mouse Anti-ATCAY Recombinant Antibody (CBLNA-119) (CBMAB-1156-CN)

This product is a mouse antibody that recognizes ATCAY of human. The antibody CBLNA-119 can be used for immunoassay techniques such as: WB, ELISA.
See all ATCAY antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLNA-119
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
Partial recombinant (aa. 3-69) from human ATCAY (NP_149053) with GST tag.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Localized in aa. 3-69

Target

Full Name
ataxia, cerebellar, Cayman type
Introduction
This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic moleculesThis protein functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. The protein may play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, it may regulate the localization of mitochondria within axons and dendrites.
Entrez Gene ID
85300
UniProt ID
Q86WG3
Alternative Names
CLAC; BNIP-H
Function
Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites.
Biological Process
Apoptotic process Source: GO_Central
Mitochondrion distribution Source: UniProtKB
Negative regulation of glutamate metabolic process Source: UniProtKB
Neuron projection development Source: UniProtKB
Polyphosphate catabolic process Source: GO_Central
Regulation of protein localization Source: UniProtKB
Cellular Location
Cytoplasm; Mitochondrion; Axon; Dendrite; Presynapse; Growth cone
Involvement in disease
Cerebellar ataxia, cayman type (ATCAY): Found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood.
PTM
Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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