Mouse Anti-ATE1 Recombinant Antibody (2B6) (CBMAB-A0554-LY)

Name: Mouse Anti-ATE1 Recombinant Antibody (2B6)
SKU: CBMAB-A0554-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B6

Application

WB, ELISA

Immunogen

ATE1 (NP_001001976, 1 a.a. ~ 87 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

arginyltransferase 1

Introduction

This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]

Entrez Gene ID

11101

UniProt ID

O95260

Alternative Names

MGC26724

Function

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).

Biological Process

Proteasomal protein catabolic process Source: MGI
Protein arginylation Source: GO_Central

Cellular Location

Isoform ATE1-1: Cytoplasm; Nucleus
Isoform ATE1-2: Cytoplasm

Fina, M. E., Wang, J., Nikonov, S. S., Sterling, S., Vardi, N., Kashina, A., & Dong, D. W. (2021). Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses. Scientific reports, 11(1), 1-20.

Kalinina, M., Skvortsov, D., Kalmykova, S., Ivanov, T., Dontsova, O., & Pervouchine, D. D. (2021). Multiple competing RNA structures dynamically control alternative splicing in the human ATE1 gene. Nucleic Acids Research, 49(1), 479-490.

Xu, C., Li, Y. M., Sun, B., Zhong, F. J., & Yang, L. Y. (2021). ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling. Molecular Cancer Research.

Jiang, C., Moorthy, B. T., Patel, D. M., Kumar, A., Morgan, W. M., Alfonso, B., ... & Zhang, F. (2020). Regulation of Mitochondrial Respiratory Chain Complex Levels, Organization, and Function by Arginyltransferase 1. Frontiers in cell and developmental biology, 8.

Singh, K., Gupta, A., Sarkar, A., Gupta, I., Rana, S., Sarkar, S., & Khan, S. (2020). Arginyltransferase knockdown attenuates cardiac hypertrophy and fibrosis through TAK1-JNK1/2 pathway. Scientific reports, 10(1), 1-11.

KASU, Y. A. T., DASGUPTA, R., & BROWER, C. S. (2020). A FLUORESCENCE-BASED REPORTER OF ARGINYLTRANSFERASE 1 (ATE1). Texas Journal of Microscopy, 51(1).

Birnbaum, M. D., Zhao, N., Moorthy, B. T., Patel, D. M., Kryvenko, O. N., Heidman, L., ... & Zhang, F. (2019). Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis. Oncogene, 38(6), 838-851.

Wang, J., Pavlyk, I., Vedula, P., Sterling, S., Leu, N. A., Dong, D. W., & Kashina, A. (2017). Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development. Developmental biology, 430(1), 41-51.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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