Rabbit Anti-ATP1A2 Recombinant Antibody (EG299) (CBMAB-EN329-LY)

ATPase Na+/K+ Transporting Subunit Alpha 1

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

ATPase Na+/K+ Transporting Subunit Alpha 1; Sodium Pump Subunit Alpha-1; EC 3.6.3.9; Sodium/Potassium-Transporting ATPase Subunit Alpha-1; Sodium-Potassium ATPase Catalytic Subunit Alpha-1; ATPase, Na+/K+ Transporting, Alpha 1 Polypeptide; Na(+)/K(+) ATPase Alpha-1 Subunit; EC 3.6.3;

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.

Adult locomotory behavior Source: Ensembl
Amygdala development Source: ARUK-UCL
ATP metabolic process Source: BHF-UCL
Behavioral fear response Source: ARUK-UCL
Cardiac muscle contraction Source: BHF-UCL
Cation transmembrane transport Source: ARUK-UCL
Cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Cellular potassium ion homeostasis Source: BHF-UCL
Cellular response to mechanical stimulus Source: Ensembl
Cellular response to steroid hormone stimulus Source: BHF-UCL
Cellular sodium ion homeostasis Source: BHF-UCL
Ion transmembrane transport Source: Reactome
Locomotion Source: ARUK-UCL
Locomotory exploration behavior Source: ARUK-UCL
Membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
Membrane repolarization Source: BHF-UCL
Negative regulation of calcium:sodium antiporter activity Source: BHF-UCL
Negative regulation of calcium ion transmembrane transport Source: BHF-UCL
Negative regulation of cytosolic calcium ion concentration Source: ARUK-UCL
Negative regulation of heart contraction Source: ARUK-UCL
Negative regulation of striated muscle contraction Source: Ensembl
Neurotransmitter uptake Source: ARUK-UCL
Olfactory cortex development Source: ARUK-UCL
Positive regulation of heart contraction Source: ARUK-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Potassium ion transmembrane transport Source: ARUK-UCL
Potassium ion transport Source: UniProtKB
Proton transmembrane transport Source: GO_Central
Regulation of blood pressure Source: Ensembl
Regulation of cardiac conduction Source: Reactome
Regulation of cardiac muscle cell contraction Source: Ensembl
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of glutamate uptake involved in transmission of nerve impulse Source: BHF-UCL
Regulation of muscle contraction Source: ARUK-UCL
Regulation of respiratory gaseous exchange by nervous system process Source: ARUK-UCL
Regulation of smooth muscle contraction Source: Ensembl
Regulation of striated muscle contraction Source: UniProtKB
Regulation of synaptic transmission, glutamatergic Source: BHF-UCL
Regulation of the force of heart contraction Source: ARUK-UCL
Regulation of vasoconstriction Source: Ensembl
Relaxation of cardiac muscle Source: BHF-UCL
Response to auditory stimulus Source: ARUK-UCL
Response to glycoside Source: BHF-UCL
Response to nicotine Source: Ensembl
Sodium ion export across plasma membrane Source: BHF-UCL
Sodium ion transmembrane transport Source: ARUK-UCL
Sodium ion transport Source: UniProtKB
Transport across blood-brain barrier Source: ARUK-UCL
Visual learning Source: Ensembl

Cell membrane; Membrane

Migraine, familial hemiplegic, 2 (FHM2): A subtype of migraine with aura associated with hemiparesis in some families. Migraine is a disabling symptom complex of periodic headaches, usually temporal and unilateral. Headaches are often accompanied by irritability, nausea, vomiting and photophobia, preceded by constriction of the cranial arteries. Migraine with aura is characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred vision, hallucinations, vertigo, numbness and difficulty in concentrating and speaking.
Alternating hemiplegia of childhood 1 (AHC1): A rare syndrome of episodic hemi- or quadriplegia lasting minutes to days. Most cases are accompanied by dystonic posturing, choreoathetoid movements, nystagmus, other ocular motor abnormalities, autonomic disturbances, and progressive cognitive impairment. It is typically distinguished from familial hemiplegic migraine by infantile onset and high prevalence of associated neurological deficits that become increasingly obvious with age.

Cytoplasmic: 6-85 aa
Helical: 86-106 aa
Extracellular: 107-129 aa
Helical: 130-150 aa
Cytoplasmic: 151-286 aa
Helical: 287-306 aa
Extracellular: 307-318 aa
Helical: 319-336 aa
Cytoplasmic: 337-769 aa
Helical: 770-789 aa
Extracellular: 790-799 aa
Helical: 800-820 aa
Cytoplasmic: 821-840 aa
Helical: 841-863 aa
Extracellular: 864-915 aa
Helical: 916-935 aa
Cytoplasmic: 936-948 aa
Helical: 949-967 aa
Extracellular: 968-982 aa
Helical: 983-1003 aa
Cytoplasmic: 1004-1020 aa