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Mouse Anti-ATP5MC2 Recombinant Antibody (EG303) (CBMAB-EN334-LY)

The product is antibody recognizes ATP5MC2 . The antibody EG303 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all ATP5MC2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Mouse
Clone
EG303
Antibody Isotype
IgG2b, κ
Application
WB, FC

Basic Information

Immunogen
Bovine Complex V.
Specificity
Human, Cattle, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)5 µg/ml
FC1 µg/ 10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ATP Synthase Membrane Subunit C Locus 2
Introduction
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. This gene has multiple pseudogenes. [provided by RefSeq, Jan 2018]
Entrez Gene ID
517
UniProt ID
Q06055
Alternative Names
ATP Synthase Membrane Subunit C Locus 2; ATP Synthase, H+ Transporting, Mitochondrial Fo Complex Subunit C2 (Subunit 9); ATP5G2; ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C2 (Subunit 9); ATP Synthase Proton-Transporting Mitochondrial F(0) Complex Subunit C2; ATP Synthase Proteolipid P2; ATPase Subunit C; ATPase Protein 9; ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit C (Subunit 9), Isoform 2;
Function
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Biological Process
ATP biosynthetic process Source: Reactome
ATP synthesis coupled proton transport Source: GO_Central
Cristae formation Source: Reactome
Mitochondrial ATP synthesis coupled proton transport Source: Reactome
Cellular Location
Mitochondrion membrane
PTM
Trimethylated by ATPSCKMT at Lys-109. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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