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Mouse Anti-ATP6V1C2 Recombinant Antibody (EG309) (CBMAB-EN340-LY)

The product is antibody recognizes ATP6V1C2 . The antibody EG309 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all ATP6V1C2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
EG309
Antibody Isotype
IgG2b, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Recombinant V-ATPase C2 of human origin.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ATPase H+ Transporting V1 Subunit C2
Introduction
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A,three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
245973
UniProt ID
Q8NEY4
Alternative Names
ATPase H+ Transporting V1 Subunit C2; ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C2; Vacuolar Proton Pump Subunit C 2; ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C Isoform 2; ATPase, H+ Transporting, Lysosomal 42kD, V1 Subunit C Isoform 2; V-Type Proton ATPase Subunit C 2;
Function
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Biological Process
Cellular response to amino acid starvation Source: Reactome
Insulin receptor signaling pathway Source: Reactome
Ion transmembrane transport Source: Reactome
Phagosome acidification Source: Reactome
Positive regulation of Wnt signaling pathway Source: UniProtKB
Regulation of macroautophagy Source: ParkinsonsUK-UCL
Transferrin transport Source: Reactome
Cellular Location
Cytosol; Extracellular exosome; Lysosomal membrane; Vacuolar proton-transporting V-type ATPase, V1 domain
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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