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Mouse Anti-ATXN10 Recombinant Antibody (CBFYE-0309) (CBMAB-E0591-FY)

This product is mouse antibody that recognizes ATXN10. The antibody CBFYE-0309 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all ATXN10 antibodies
Published Data
Mouse Anti-ATXN10 Recombinant Antibody (CBFYE-0309) in WB
Ataxin-10 siRNAs or control siRNAs were transfected transiently into HUVECs. 48 h later, transfected cells were stimulated with TNF-α (10 ng/mL) for 0, 4, 8, and 24 h. Protein levels of VCAM-1, ICAM-1, and VE-cadherin were determined. ...View More
Li, Y., Zhang, Q., Li, N., Ding, L., Yi, J., Xiao, Y., ... & Huang, X. (2021). Ataxin-10 inhibits TNF-α-induced endothelial inflammation via suppressing interferon regulatory factor-1. Mediators of Inflammation, 2021.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-0309
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 15-190 mapping near the N-terminus of Ataxin-10 of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ataxin-10
Introduction
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade.
Entrez Gene ID
25814
UniProt ID
Q9UBB4
Alternative Names
E46L; SCA10; HUMEEP
Function
Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
Biological Process
Cilium assembly Source: Ensembl
Nervous system development Source: UniProtKB
Neuron projection development Source: UniProtKB
Cellular Location
Perinuclear region
Involvement in disease
Spinocerebellar ataxia 10 (SCA10): Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
Defects in ATXN1 may be a cause of nephronophthisis a chronic tubulo-interstitial nephropathy that leads to anemia, polyuria, polydipsia, isosthenuria and death in uremia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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