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Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) (CBMAB-Z0013-WJ)

This product is a mouse antibody that recognizes AZGP1. The antibody CBWJZ-006 can be used for immunoassay techniques such as: ICC.
See all AZGP1 antibodies
Published Data
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB
Western blot showed that ZAG protein level was significantly decreased in seizure (n=5 cell cultures containing pooled brains from 4 rats). The optical density was normalized by β-actin and Controls. All bar graph data are presented as the mean±SD. *p<0.05, **p<0.01. ...View More
Peng, W., Liu, X., Tan, C., Zhou, W., Jiang, J., Zhou, X., ... & Chen, L. (2021). Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression. Journal of Neurochemistry, 157(3), 695-709.
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB
Hepatic protein levels in rats were analyzed by western blot, respectively. GAPDH protein was used as a control. (A) SREBP1 protein level. (B) HSL protein level. (C) FAS protein level. (D) ZAG protein level. (E) ERα protein level. (F) TLR4 protein level. (G) NF-κB protein level. (H) IκBα protein level. ...View More
Lin, R., Jia, Y., Wu, F., Meng, Y., Sun, Q., & Jia, L. (2019). Combined exposure to fructose and bisphenol a exacerbates abnormal lipid metabolism in liver of developmental male rats. International journal of environmental research and public health, 16(21), 4152.
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in IF
Double-label immunofluorescence showed co-expression of ZAG with NeuN. ...View More
Wei, X., Liu, X., Tan, C., Mo, L., Wang, H., Peng, W., ... & Chen, L. (2019). Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons. NeuroReport, 30(8), 580-585.
Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB
Western blots of ZAG in liver, brown and white fat, and 3T3-L1 adipocytes (day 15 after differentiation). ...View More
Bing, C., Bao, Y., Jenkins, J., Sanders, P., Manieri, M., Cinti, S., ... & Trayhurn, P. (2004). Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proceedings of the National Academy of Sciences, 101(8), 2500-2505.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJZ-006
Antibody Isotype
IgG1, κ
Application
WB, IP, IF

Basic Information

Immunogen
Purified Zn-α2- glycoprotein (ZAG) of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml

Target

Full Name
Alpha-2-Glycoprotein 1, Zinc-Binding
Introduction
AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include Hidrocystoma and Clear Cell Hidradenoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include antigen binding and peptide antigen binding. An important paralog of this gene is HFE.
Entrez Gene ID
Human563
Mouse12007
UniProt ID
HumanP25311
MouseQ64726
Alternative Names
ZAG; ZA2G
Function
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.
Biological Process
Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
Cell adhesion Source: UniProtKB
Detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Retina homeostasis Source: UniProtKB
Transmembrane transport Source: Reactome
Cellular Location
Secreted
PTM
N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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