Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) (CBMAB-Z0013-WJ)

Name: Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006)
SKU: CBMAB-Z0013-WJ
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB

Western blot showed that ZAG protein level was significantly decreased in seizure (n=5 cell cultures containing pooled brains from 4 rats). The optical density was normalized by β-actin and Controls. All bar graph data are presented as the mean±SD. *p<0.05, **p<0.01. ...View More

Peng, W., Liu, X., Tan, C., Zhou, W., Jiang, J., Zhou, X., ... & Chen, L. (2021). Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression. Journal of Neurochemistry, 157(3), 695-709.

Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB

Hepatic protein levels in rats were analyzed by western blot, respectively. GAPDH protein was used as a control. (A) SREBP1 protein level. (B) HSL protein level. (C) FAS protein level. (D) ZAG protein level. (E) ERα protein level. (F) TLR4 protein level. (G) NF-κB protein level. (H) IκBα protein level. ...View More

Lin, R., Jia, Y., Wu, F., Meng, Y., Sun, Q., & Jia, L. (2019). Combined exposure to fructose and bisphenol a exacerbates abnormal lipid metabolism in liver of developmental male rats. International journal of environmental research and public health, 16(21), 4152.

Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in IF

Double-label immunofluorescence showed co-expression of ZAG with NeuN. ...View More

Wei, X., Liu, X., Tan, C., Mo, L., Wang, H., Peng, W., ... & Chen, L. (2019). Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons. NeuroReport, 30(8), 580-585.

Mouse Anti-AZGP1 Recombinant Antibody (CBWJZ-006) in WB

Western blots of ZAG in liver, brown and white fat, and 3T3-L1 adipocytes (day 15 after differentiation). ...View More

Bing, C., Bao, Y., Jenkins, J., Sanders, P., Manieri, M., Cinti, S., ... & Trayhurn, P. (2004). Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proceedings of the National Academy of Sciences, 101(8), 2500-2505.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJZ-006

Application

WB, IP, IF

Immunogen

Purified Zn-α2- glycoprotein (ZAG) of human origin.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

More Infomation

Target

Full Name

Alpha-2-Glycoprotein 1, Zinc-Binding

Introduction

AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include Hidrocystoma and Clear Cell Hidradenoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. Gene Ontology (GO) annotations related to this gene include antigen binding and peptide antigen binding. An important paralog of this gene is HFE.

Entrez Gene ID

Human	563
Mouse	12007

UniProt ID

Human	P25311
Mouse	Q64726

Alternative Names

ZAG; ZA2G

Function

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Biological Process

Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
Cell adhesion Source: UniProtKB
Detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Retina homeostasis Source: UniProtKB
Transmembrane transport Source: Reactome

Cellular Location

Secreted

PTM

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.

Cao, R., Ke, M., Wu, Q., Tian, Q., Liu, L., Dai, Z., ... & Liu, P. (2019). AZGP1 is androgen responsive and involved in AR‐induced prostate cancer cell proliferation and metastasis. Journal of cellular physiology, 234(10), 17444-17458.

Faulconnier, Y., Boby, C., Pires, J., Labonne, C., & Leroux, C. (2019). Effects of Azgp1−/− on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice. Gene, 692, 201-207.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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