Rabbit Anti-AZI2 Recombinant Antibody (EG326) (CBMAB-EN363-LY)

The product is antibody recognizes AZI2 . The antibody EG326 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all AZI2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG326

Antibody Isotype

IgG

Application

WB, IF, ICC

Basic Information

Immunogen

A synthesized peptide derived from human TAF3.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:2,000
IF(ICC)	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 150mM NaCl, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

5-Azacytidine Induced 2

Introduction

AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

Human	64343
Mouse	27215
Rat	316051

UniProt ID

Human	Q9H6S1
Mouse	Q9QYP6
Rat	D4A693

Alternative Names

5-Azacytidine Induced 2; NF-Kappa-B-Activating Kinase-Associated Protein 1; NAP1; TILP; 5-Azacytidine-Induced Protein 2; 5-Azacytidine Induced Gene 2;

Function

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.

Biological Process

Dendritic cell differentiation Source: Ensembl
Dendritic cell proliferation Source: Ensembl
I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Mitotic cell cycle Source: Ensembl
T cell activation Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Cytoplasm

References

Zhou, X., Barkley‐Levenson, A. M., Montilla‐Perez, P., Telese, F., & Palmer, A. A. (2021). Functional validation of a finding from a mouse genome‐wide association study shows that Azi2 influences the acute locomotor simulant response to methamphetamine. Genes, Brain and Behavior, e12760.

Zhou, X., Barkley-Levenson, A., Montilla-Perez, P., Telese, F., & Palmer, A. A. (2020). Functional validation of a finding from a mouse genome-wide association study demonstrates that a mutant allele of Azi2 alters sensitivity to methamphetamine. bioRxiv.

Liu, K., Yu, J., Zhao, J., Zhou, Y., Xiong, N., Xu, J., ... & Lin, Z. (2018). AZI2 3’UTR is a new SLC6A3 downregulator associated with an epistatic protection against substance use disorders. Molecular neurobiology, 55(7), 5611-5622.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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