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Mouse Anti-B4GALT3 Recombinant Antibody (CBYY-0094) (CBMAB-0094-YY)

This product is mouse antibody that recognizes B4GALT3. The antibody CBYY-0094 can be used for immunoassay techniques such as: WB
See all B4GALT3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-0094
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 100-393 of human B4GALT3 produced in E.coli.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beta-1,4-Galactosyltransferase 3
Introduction
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
8703
UniProt ID
O60512
Alternative Names
Beta-1,4-Galactosyltransferase 3; UDP-Galactose:Beta-N-Acetylglucosamine Beta-1,4-Galactosyltransferase 3; UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 3; UDP-Gal:Beta-GlcNAc Beta-1,4-Galactosyltransferase 3; Beta-1,4-GalTase 3; Beta4Gal-T3; B4Gal-T3; Beta-N-Acetylglucosaminyl-Glycolipid Beta-1,4-Galactosyltransferase 3; EC 2.4.1.-;
Function
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
Biological Process
Carbohydrate metabolic process Source: InterPro
Galactosylceramide biosynthetic process Source: BHF-UCL
Glycosylation Source: GO_Central
Keratan sulfate biosynthetic process Source: Reactome
Protein glycosylation Source: UniProtKB-UniPathway
Cellular Location
Golgi stack membrane. Trans cisternae of Golgi stack.
Topology
Cytoplasmic: 1-10 aa
Helical: 11-31 aa
Lumenal: 32-393 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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